background and aims: this study examined sub-chronic effects of methamphetamine (meth) on the stereological parameters in the cornu ammonis (ca) of the hippocampus in adult mice. materials and methods: fifteen adult male mice, eight weeks old, were randomly divided into three groups: receive saline (controls), or low-dose (ld) 2.5 mg/kg meth, or high-dose (hd) 25 mg/kg meth, via daily intraperi...

the effects of chronic administration of lithium, on acute toxicity of chlorpromazine (cpz) in male albino mice was studied and the ldso values were determined from dose-probit curves. tfie results showed that in lithium pretrealed animals (anmials consumed drinking water containing 600mg/l lithium chloride for 10 days) the ld50 value (the dose corresponding to probit 5) of cpz increased signif...

background: in the present investigation radiation and cadmium induced biochemical changes in the kidney of swiss albino mice have been studied. materials and methods: for this purpose, adult male swiss albino mice (6-8 weeks old) were divided into four groups. group i (sham-irradiated), group ii (treated with cdcl2 solution 20 ppm), group iii (irradiated with 1.25, 2.5 and 5.0 gy gamma rays), ...

background: saccharin is an artificial non-caloric sweetener that used to sweeten products such as drinks, candies, medicines, and toothpaste, but our bodies cannot metabolize it. sodium saccharin is considered as an important factor in tumor promotion in male rats but not in humans. objective: the objective of this study was to investigate the effect of saccharin consumption on sperm parameter...

background: diabetes mellitus (dm), primary or idiopathic is a chronic disorder of the carbohydrate, lipid and protein metabolism. dm may impact male reproductive function at several levels. it is shown that dm has detrimental effects on sperm parameters in human and experimental animals. objective: the aim of this study was to observe the effects of diabetes on sperm parameters (viability, cou...

introduction: there is evidence that diabetes affects seizure susceptibility. ginger (zingiber officinale roscoe) which is used in traditional medicine has antioxidant activity and neuroprotective effects. the aim of this study was to evaluate the seizure threshold induced by pentylenetetrazole (ptz) in diabetic mice after induction of diabetes with streptozocin and to examine the possible role...

since the uterine is a sensitive tissue to steroid hormones, the aim of the present study was to investigate the effects of 17β-estradiol (e2) and progesterone (p4) alone or in combination on morphological and morphometrically parameters of ovariectomized mouse uterus.adult virgin female mice (8-10 weeks old)were ovariectomized and treated with e2, p4, e2 followed by p4 and the oil vehicle alon...

creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. creatine supplements have shown beneficial effects on neurological disorders including parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, alzheimer's disease and stroke. however, the potential benefits of creatine for pati...

background: cystic echinococcosis (ce), also known as echinococcosis/hydatidosis, is one of the most important parasitic diseases in the world. it enhances both humoral and cellular (th1 and th2) responses in infected host. different antigens of the worm may favor the th1 or th2 immune responses in ce patients. objective: to evaluate the humoral and cellular immune responses of balb/c mice agai...

background pomegranate (punica granatum) is a significant source of bioactive compounds. however, its toxicity is not intensively studied. objectives the current study investigated the safety and tolerability of pomegranate peel extract (ppe) in balb/c mice. conclusions the current study showed that ppe had no toxicity and its use is suggested with potential applications against diseases. resul...