A simple, sensitive and accurate method based on high performance liquid chromatography (HPLC) with diode array detector (DAD) was developed and validated for systematic quality evaluation of one type of traditional Chinese medicine preparations named Xinkeshu (XKS) tablet. In this study, the chromatographic fingerprints of XKS tablet were developed first, 23 peaks were selected as the common p...

We have previously demonstrated that DT-010, a novel conjugate of danshensu (DSS) and tetramethylpyrazine (TMP), displays anti-tumor effects in breast cancer cells both in vitro and in vivo. In the present study, we investigated whether DT-010 enhances the chemotherapeutic effect of doxorubicin (Dox) in MCF-7 breast cancer cells and exerts concurrent cardioprotective benefit at the same time. O...

Danshen, the root of Salvia miltiorrhiza, is one of the most commonly used traditional chinese herbs. owing to its remarkable and reliable biological activities, especially in the treatment of cardiovascular disorders, it is widely used either alone or in combination with other herbal ingredients for patients with coronary artery disease in china and other countries.1 Phenolic acids and lipophi...

Aim This study is to determine seven phenolic constituents (salvianolic acid A, salvianolic acid B, rosmarinic acid, caffeic acid, protocatechuic aldehyde, protocatechuic acid, danshensu) of isolated from Radix Salvia miltiorrhizae in rat plasma and to study the pharmacokinetics of the seven phenolic constituents. Methods A rapid and sensitive method for the determination of seven phenolic cons...

OBJECTIVES Salvia miltiorrhiza (SM) is a popular and classic herb in traditional Chineses medicines. The objective is to confirm the effects of aqueous extract of S. miltiorrhiza (ESM) and its main ingredient on the promotion of orthodontic tooth movement and healing of periodontal ligament in rat. MATERIALS AND METHODS Male Sprague-Dawley rats (n= 150) were divided into five groups: model co...

Danshensu (DSU) and salvianolic acid B (SAB) are the primary water-soluble compounds of Salvia miltiorrhiza Bunge (Lamiaceae). In this study, we analyzed the effects of DSU, SAB and a S. miltiorrhiza extract (SME) on cell proliferation. Additionally, the effects of DSU and SAB on collagen synthesis in Detroit 551 human normal fibroblast cells and on melanin production in B16 melanoma cells were...

The aim of the present study was to investigate the effect of salvianolic acid B (Sal B) and danshensu (DSU) on the osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) and the mechanisms of the effects. The osteogenic differentiation of MSCs in culture was assessed by measuring alkaline phosphatase (ALP) activity, osteocalcin (OCN) production, nitric oxide (NO) production an...