Photopharmacological control of neuronal activity using synthetic photochromic ligands, or photoswitches, is a promising approach for restoring visual function in patients suffering from degenerative retinal diseases. Azobenzene photoswitches, such as AAQ and DENAQ, have been shown to restore the responses of retinal ganglion cells to light in mouse models of retinal degeneration but do not rec...

Background and Objectives:The mechanism responsible for the generation of ectopic beats in pulmonary veins (PVs) remains to be well defined. The present study examines the electrophysiological characteristics of the PVs and other regions of the canine left atrium (LA) under low dose (300 μM) caffeine condition. Materials and Methods:Transmembrane action potentials were recorded from the left su...

The Discharge Abstract Database (DAD) is one of the key data holdings held by the Canadian Institute for Health Information (CIHI). The Institute is a national, not-for-profit organization, which plays a critical role in the development of Canada's health information system. The Discharge Abstract Database contains acute care discharge data from most Canadian hospitals. The data generated are e...

OBJECTIVE To determine the data sources and 'look back' intervals to define comorbidities. DATA SOURCES Hospital discharge abstracts database (DAD), physician claims, population registry and death registry from April 1, 1994 to March 31, 2010 in Alberta, Canada. STUDY DESIGN Newly-diagnosed hypertension cases from 1997 to 2008 fiscal years were identified and followed up to 12 years. We def...

Repression of gene transcription is linked to regulation of chromatin structure through deacetylation of core histone amino-terminal tails. This action is mediated by histone deacetylases (HDACs) that function within active multiprotein complexes directed to the promoters of repressed genes. In vivo, HDAC3 forms a stable complex with the SMRT corepressor. The SMRT-HDAC3 complex exhibits histone...

INTRODUCTION Diffuse alveolar damage (DAD) is a morphological prototype of acute interstitial pneumonia. Hospital autopsies or open-lung biopsies are used to monitor common alveolar damage and hyaline membrane (HM) development histopathologically. The aim of this study was to detect histopathological profiles and frequency of DAD and HM in adult forensic autopsies. MATERIALS AND METHODS In to...

UNLABELLED Dento-alveolar disharmony (DAD) with crowding represents a predispose factor for periodontal pathology installing, especially when septic inflammation is associated. In this context, the identification of integrity or presence of the periodontal structure modifications becomes essential, any discovered element of periodontal pathology transforming into an important factor for a corre...

Analysis of rubber and rubberwood biomass management revealed an actualized twin-loop circularity arising from the multibillion-dollar export revenue downstream upstream segments. Despite resembling zero-waste resource-efficient system, natural exports does not translate as wealth smallholders, pressing them persistent ‘poor dad’ in value chain. This study dwells on how to empower smallholders ...

functions of the nervous system. He also furnishes us with the particulars of the experiments which he has recently made, with the view of elucidating some of the most difficult problems in physiology. He has moreover, in common with other physiological psychologists, had the presumption to suppose that the recent researches and conflicting experiments made both in this country and on the Conti...

high performance liquid chromatography coupled with photodiode array detector (hplc-dad) has been reported to quantify isolated flavonoids or these compounds in complex biological matrices, such as chinese herbal drugs and products from factories. this work was designed, therefore, to develop an hplc-dad system to separate quercetin, luteolin and apigenin and to quantify them in extractive solu...