This paper proposes a reconfigurable current steering digital to analog converter (DAC). The differential non-linearity error (DNL) of the DAC is estimated on-chip. This is used to reconfigure the switching sequence to get a lower integral nonlinearity error (INL). A 10 bit segmented DAC along with the associated circuits for DNL estimation was designed and fabricated using 0.35μm CMOS technolo...

Gamma delta (γδ) T cells, which possess potent cytotoxicity against a wide range of cancer cells, have become a potential avenue for adoptive immunotherapy. Decitabine (DAC) has been reported to enhance the immunogenicity of tumor cells, thereby reinstating endogenous immune recognition and tumor lysis. However, DAC has also been demonstrated to have direct effects on immune cells. In this stud...

BACKGROUND ROC curve analysis is used to compare the overall diagnostic accuracy of tests, but its application to subgroups selected by a concentration range of only one marker may show severe biases. We developed a new approach, which we have named discordance analysis characteristics (DAC). METHODS The DAC method is based on a generalization of the McNemar test so that for a given pair of c...

A multi-center study from the French Myelodysplastic Syndrome (MDS) Group confirmed that iron chelation therapy is an independent prognostic factor that can increase the survival rate of patients who are suffering from transfusion-dependent low-risk MDS. In this study, we aimed to explore this clinical phenomena in vitro, by exploring the synergistic effect of the iron chelator Deferasirox (DFX...

Purpose: Our study was to detect the effect of Decitabine (DAC) combined with arsenic trioxide (AS2O3) on DAPK gene and HL-60 cell proliferation and apoptosis. Methods: DAC and AS2O3 monotherapy, combination treatment and DAC pretreatment were used in this study after incubating with HL-60 cell for 24 h, 48 h, 72 h. CCK8 was used to detect the cell proliferation of HL-60 cell. Flow cytometry wa...

This paper describes sampling clock jitter effects in digital-to-analog converters. A formula for the output error power due to sampling clock jitter for a sinusoidal input is derived and verified by numerical simulations, and its spectrum characteristics is shown. Also its effects on DAC SNR is clarified by numerical simulation as follows: (i) When the total noise power outside as well as insi...

The neural stimulators have been employed to the visual prostheses system based on the functional electrical stimulation (FES). Due to the size limitation of the implantable device, the smaller area of the unit current driver pixel is highly desired for higher resolution current stimulation system. This paper presents a 16-channel compact current-mode neural stimulator IC with digital to analog...

A second-order audio analog-to-digital converter (ADC) modulator using a second-order 33-level tree-structured mismatch-shaping digital-to-analog converter (DAC) is presented. Key logic simplifications in the design of the mismatch-shaping DAC encoder are shown which yield the lowest complexity second-order mismatch-shaping DAC known to the authors. The phenomenon of signal-dependent DAC noise ...