Pneumococcal bacteriocins (pneumocins) are antibacterial toxins that mediate intra-species competition within the human host. However, the triggers of pneumocin expression are poorly understood. Using RNA-sequencing, we mapped the regulon of the pneumocin cluster (blp) of Streptococcus pneumoniae D39. Furthermore, by analogy with pneumococcal competence, we show that several antibiotics activat...

Th e multiplicity of policies proposed to support the informal sector refl ects the lack of a common defi nition. Although they may produce positive eff ects, these are limited and fail to constitute a comprehensive strategic approach. Th e diff erent interpretations in the absence of a common defi nition as well as the strategies emerging from them are reviewed. Th e identifi cation of informa...

The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in strains D39 (type 2) and A66 (type 3), and the mutants were tested by being injected intravenously into mice. The animals infected with the mutant strains showed a significant increase in survival, wit...

Inequality of Learning in Industrialised Countries Within-country differences in educational outcomes are compared for a large group of industrialised countries. We investigate where inequality is greatest, the association between inequality in learning and average levels of learning, the interpretation of measured levels of inequality, and differences in inequality at the top and bottom of the...

This work aims at defining and implementing a multi-media model within the TAXATA (Things Are eXactly As They Appear) model used in the Views project, which supplies a consistent and integrated open-architecture application environment. Dynamic objects, having a time dimension, structuring operators, presentation and accessing methods have been integrated into the current Views model. Relations...

The catalase-negative, facultative anaerobe Streptococcus pneumoniae D39 is naturally resistant to hydrogen peroxide (H2O2) produced endogenously by pyruvate oxidase (SpxB). Here, we investigate the adaptive response to endogenously produced H2O2. We show that lactate oxidase, which converts lactate to pyruvate, positively impacts pyruvate flux through SpxB and that ΔlctO mutants produce signif...

We report a search for small RNAs (sRNAs) in the low-GC, gram-positive human pathogen Streptococcus pneumoniae. Based on bioinformatic analyses by Livny et al. (J. Livny, A. Brencic, S. Lory, and M. K. Waldor, Nucleic Acids Res. 34:3484-3493, 2006), we tested 40 candidates by Northern blotting and confirmed the expression of nine new and one previously reported (CcnA) sRNAs in strain D39. CcnA ...

PspA is a cell surface protein of Streptococcus pneumoniae that is present on a number of clinical isolates as well as the nonencapsulated laboratory strain Rx1. In a previous report we have shown that mAbs directed against PspA can protect mice from at least some of the pneumococcal strains bearing this protein. In our present report we have produced insertional inactivation mutants that lack ...