We examined the effect of dietary conjugated linoleic acid (CLA) on liver regeneration after a partial hepatectomy (PH) in Sprague-Dawley rats. PH was performed on rats fed a 0 or 1 wt.% CLA diet for 3 wk. Average liver weight in the CLA fed rat population was heavier than the control rat population at the time of PH and 1-d after PH. Conversely. CLA fed rats' liver weight was significantly low...

4-Chlorobutyryl group was used as amino protective group for n(-)-alpha-phenylglycine (I). N-Hydroxysuccinimide ester III was prepared in high yield but partly racemic. Reaction of III or IV with V afforded epimeric mixtures of N,0-protected cephalexins (VI), which can be separated by crystallisation. The 4-chlorobutyryl group in VII was removed under very mild conditions giving cephalexin (IX)...

normal 0 false false false en-us x-none ar-sa background: there have been few studies to examine the effect of magnesium (mg) supplementation on liver enzymes. the aim of this study was to evaluate the effect of mg supplementation and weight loss on liver enzymes, lipid profile, and fasting blood sugar in patients with nonalcoholic fatty liver disease (nafld). materials and methods: this study ...

A short overview is given of new developments in the chemo-enzymatic synthesis of amino acids. Amino acid resolution procedures based on stereoselective enzymatic hydrolysis of amino acid amides have been developed. Two enzymes, an aminopeptidase from Pseudomonas putida and an amidase from Hycobacterium neoaurum have been purified to homogeneity. In addition, methods for the stereoselective syn...

Dengue virus is an increasingly global pathogen. One of the promising targets for antiviral drug discovery against dengue and related flaviviruses such as West Nile virus is the viral serine protease NS2B-NS3. We here report the synthesis and in vitro characterization of potent peptidic inhibitors of dengue virus protease that incorporate phenylalanine and phenylglycine derivatives as arginine-...

The activity of aspartate aminotransferase a vitamin B6 containing enzyme was measured in the laysed synaptosomes prepared from rat brain, during development. Administration of vitamin B6 increased the enzyme activity throughout development. The stimulating effect of this vitamin was prevented when the animals were previously treated with D-penicillamine. However, penicillamine alone had n...

Some biochemical properties of whole-cell penicillin amidohydrolase from Micrococcus luteus have been studied. This whole-cell enzyme showed its maximal activity at 36 degrees C at pH 7.5. It was found that the activation energy of this enzyme was 8.03 kcal (ca. 33.6 kJ) per mol, and this amidohydrolase showed first-order decay at 36 degrees C. The penicillin amidohydrolase was deactivated rapi...

the substrate α-hydrogen. It shows no structural similarity to other enzymes, but the structure of active center is closely similar to the heme binding site of hemoglobin and myoglobin. Hemine stoichiometrically binds to the enzyme active center to inhibit the activity. Several species of B. subtilis, in particular the producers of Japanese and Korean soybean fermented food, Natto and Chungkook...