The microscopic study of a variety of tumors, by means of cytological technics not ordinarily ap plied to such tissue (19), has led to the observation of spores and other fungal structures in all types of neoplasms examined. These structures were noted initially in the debris of tumors degenerating in response to chemotherapeutic agents; later, by means of special stains, they were studied in t...

Obvious mitotic abnormalities have long been known to occur very commonly in malignant tumours, but as a result of recent improvements in technique much more reliable cytogenetic observations are now possible. Transplantable tumours were the first to be accurately examined, and these were found to consist of populations of cells with variations around a modal (" stemline ") type which differs i...

On the basis of the current available literature, the authors have presented a short description of cytological examination and its application in the oral mucosa disease diagnostic process. Furthermore, the advantages and disadvantages of this method are described. The available diagnostic tools used for oral smears were reviewed as well as more and more often available methods which aim at ma...

A detailed cytomorphologic study was done on fine needle aspiration smears from 651 benign breast lumps. Cytological categorization enabled the distinction of proliferative from non-proliferative and infective lesions in the majority of the cases. Lumpectomy provided the histological diagnosis in 584 cases, most of which were proliferative lesions. Gross cystic disease and fibroadenoma were the...

Adult T-cell leukemia (ATL) is an aggressive lymphoid proliferation associated with the human T-lymphotropic virus type I (HTLV-I). The intraocular invasion of ATL is a rare event. A 75-year-old man without any systemic disease underwent uneventful cataract surgery of the right eye. On postoperative day 6, the patient presented with blurred vision due to severe vitreous opacity in the right eye...

Molecular targeting therapy for non-small cell lung cancer (NSCLC) has clarified the importance of mutation testing when selecting treatment regimens. As a result, multiple-gene mutation tests are urgently needed. We developed a next-generation sequencer (NGS)-based, multi-gene test named the MINtS for investigating driver mutations in both cytological specimens and snap-frozen tissue samples. ...

We evaluated the diagnostic accuracy of fine-needle aspiration biopsy in a prospective study of 300 patients with previously undiagnosed bone lesions. Patients with suspected local recurrence of a primary bone tumour or a metastatic lesion of a previously diagnosed malignancy were excluded. Fine-needle aspiration biopsy was performed under radiological control as an outpatient procedure. The se...

conclusions the aspirates from the hypovascular and hypervascular sites of solid nodules are complementary and should be performed consecutively. results when only hypervascular site was used, adequate sampling was limited to 65% of the cases. when both sites were evaluated together, overall adequate sampling was 91%. adding a sample from the hypervascular site to hypovascular aspirate increase...

background and objectives : streptococcus pneumoniae is the main causative agent of acute bacterial meningitis in the world. this study aimed to detect pneumoniae infection in cerebrospinal fluid (csf) samples of patients with suspected meningitis. materials and methods : in this study, 200 csf samples in patients with suspected meningitis and with negative bacterial cultures were tested. demog...

BACKGROUND The combination of endobronchial biopsy with cytological brushing is considered the best procedures for the diagnosis of lung cancer during bronchoscopy. AIM To asses the diagnostic yield for lung cancer (with visible endobronchial alterations at endoscopy) of three fiberoptic bronchoscopy procedures: endobronchial biopsy, cytological brushing and bronchial cytological washings. ...