Background Chronic urticaria is a skin disease with an important immunologic profile. There is a great interest not only due to its special clinical manifestation, but also due to its pathogenic mechanism. New data support the participation of ILs (interleukins) in the pathophysiology of CU (chronic urticaria). The aim of this study is to explore the change and its significance of cytokines, co...

Background Cow’s milk protein (CMP) allergy (CMPA) affects 2-6% of children. The most important allergens are a-casein (ACA), a-lactoalbumin (ALA) and b-lactoglobulin (BLG). BLG, absent in human milk, is considered to be the major allergen of CMP. Little is known about T cells response and cytokines profile in relation to CMPA and tolerance acquisition. Our aim was to characterize T cells respo...

The aim of our study was to examine in vivo and in vitro cytokines produced by Lewis ratderived R5-28 sarcoma cells. These cells produce rapidly growing tumours in approximately two weeks after subcutaneous inoculation. However, spontaneous tumour regression was noted in about 40% of animals. For an explanation of this phenomenon, we evaluated the profile of 19 cytokines during tumour growth an...

Hecogenin is a steroidal sapogenin largely drawn from the plants of the genus Agave, commonly known as 'sisal', and is one of the important precursors used by the pharmaceutical industry for the synthesis of steroid hormones. Hecogenin acetate (HA) is a steroidal sapogenin-acetylated that produces antinociceptive activity. Thus, we evaluate the antihyperalgesic profile of HA in mice in inflamma...

Bipolar disorder (BD) is a severe, chronic, and recurrent psychiatric illness. It has been associated with high prevalence of medical comorbidities and cognitive impairment. Its neurobiology is not completely understood, but recent evidence has shown a wide range of immune changes. Cytokines are proteins involved in the regulation and the orchestration of the immune response. We performed a rev...

The story of cytokines goes back to last century when interferon was discovered first time. Cytokines are pleiotropic proteins or small glycoproteins with a molecular weight less than 30 kDa (˂200 amino acids) Cytokines are produced by a number of cell types, such as leukocytes which regulate immunity, inflammation and hematopoiesis [1]. About 200 cytokines are recognized to date. They have a h...

INTRODUCTION We demonstrated, in a recently published study, far more PPD negative reactivity among patients who had RA (70%) than among controls (30%). To evaluate the hypothesis that different response to PPD in RA patients is associated with different profiles of serum cytokines, we compared the serum levels of IL-2, IL-4, IL-6, IL-10, TNF alpha and IFN gamma from PPD negative and PPD positi...