BACKGROUND There is increasing evidence that a strong genetic component is involved in the predisposition to recurrent acute otitis media (rAOM). Cytokines play a key role in the pathogenesis of otitis media. Constitutional polymorphisms in cytokine genes may lead to individual variations in cytokine secretion. OBJECTIVE To elucidate the role of cytokine gene polymorphisms in rAOM. SETTING ...

Background/Aim: Alopecia areata (AA), which is characterized by hair loss, an inflammatory autoimmune disease. Tumor necrosis factor-alpha (TNFα) a potent proinflammatory cytokine that has highly significant role in and immune responses. The aim of this study to evaluate whether there relationship between TNFα -238 G/A gene polymorphism AA the Turkish population. Methods: In case-control study,...

PURPOSE Biochemotherapy can achieve high response rates in advanced melanoma, but the factors that influence regression and survival remain unknown. The present exploratory study tested the hypothesis that cytokine gene polymorphisms predict clinical outcome in stage IV melanoma patients treated with biochemotherapy. EXPERIMENTAL DESIGN Ninety patients with stage IV melanoma were treated with...

BACKGROUND Approximately half of recurrent miscarriages have unexplained etiology. Recent evidences suggest that cytokines are important determinants in pregnancy maintenance and as such, cytokine gene polymorphisms, which can affect cytokine production and/or functionality, could play a role in the disorder. Thus, we aimed to investigate the association of selected cytokine gene polymorphisms ...

Introduction: Cardiac allograft rejection is associated with an individual’s inflammatory cytokine gene polymorphism. It was hypothesized that possession of specific cytokine alleles might be influential in predisposing the recipient to allograft rejection. Methods: DNA from nucleated peripheral blood cells of 65 cardiac transplantation patients and 77 controls were tested for IL-2, TNF-a, TGF-...

late-onset alzheimer's disease (load) is a neurodegenerative disorder and the most common form of dementia affecting people over 65 years old. alzheimer’s disease is a complex disease with multi-factorial etiology. inflammation has been approved to have an important role in the pathogenesis of alzheimer’s disease (ad). tnf-a is a main pro-inflammatory cytokine that plays an essential role in in...

aim : leptin is a 16 kda polypeptide hormone which secreted by adipose tissue and has an important role in energy balance, insulin pathway and inflammation, because of that it may play an important role in colorectal cancer (crc). leptin exerts its effect through the leptin receptor (lepr) a member of the class i cytokine receptor family. background : we have investigated whether glutamine to a...

Aim: This study is mainly devoted to determining the ability of ∆FN3.1 protein fragments Bifidobacterium (B.) longum subsp. GT15, namely two FN3 domains (2D FN3) and a C-terminal domain (CD FN3), bind tumor necrosis factor-alpha (TNF-α). Methods: Fragments fn3 gene encoding 2D CD were cloned in Escherichia (E.) coli. In order assess binding specificity between TNFα, we employed previously devel...

The NLRP3 inflammasome is an intracellular multi-protein complex that triggers caspase-1 mediated maturation of interleukin-1β (IL-1β); one of the most potent mediators of inflammation and a major cytokine produced during severe infections, like sepsis. However, the excessive cytokine levels seem to stage for tissue injury and organ failure, and high levels of IL-1β correlates with severity and...

Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation could be linked to genetic factors, including genetic polymorphism. The ...