نتایج جستجو برای: cytogenetic risk groups
تعداد نتایج: 1591243 فیلتر نتایج به سال:
Internal tandem duplication (ITD) of the FLT3 gene (FLT3/ITD) has been linked to poor outcome in acute myeloid leukemia (AML). However, the prognostic value of FLT3/ITD in various cytogenetic risk groups is still a matter of debate. The aim of this study was to evaluate the prognostic significance of FLT3/ITD in patients with de novo AML and normal or favorable risk cytogenetics (NFC-AML). Bloo...
To reveal the relationship between hypodiploidy with 30 to 39 chromosomes and near-triploidy in acute lymphoblastic leukemia (ALL), we studied 24 patients presenting with one of these aneuploidies among 623 adults with ALL registered in the Leucemie Aigue Lymphoblastique de l'Adulte (LALA) protocols. The 2 ploidy groups presented a striking similarity of their cytogenetic profiles: chromosomes ...
Acute myeloid leukaemia Chemotherapy for AML is divided into two phases: induction and consolidation. The initial aim of induction treatment is to produce a “morphological complete remission” — ie, normal neutrophil and platelet counts and a reduction in the number of leukaemic blast cells to <5% of the total white blood cell count in the bone marrow. Induction regimens include cytarabine and a...
entire chromosome complement to detect numerical as well as structural aberrations. Most chromosomal aberrations in MDS can also be detected by fluorescence in situ hybridization (FISH) analyses, but only pre-defined anomalies can be covered, if a distinct informative probe is used. The IPSS/-R is based on chromosome banding analyses in primary untreated MDS patients. If a bone marrow aspiratio...
The growing use of ionizing radiation in various sectors of industry, medicine, agriculture and research has increased the risk of radiation exposure of staff and people. Ionizing radiation as a strong clastogen can cause different types of DNA damages and chromosomal aberrations. Biological dosimetry, based on the cytogenetic analysis of peripheral blood lymphocytes has a wide application in d...
BACKGROUND The molecular determinants of clinical responses to decitabine therapy in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are unclear. METHODS We enrolled 84 adult patients with AML or MDS in a single-institution trial of decitabine to identify somatic mutations and their relationships to clinical responses. Decitabine was administered at a dose of 20 ...
Genetics play an increasingly important role in the risk stratification and management of acute myeloid leukemia (AML) patients. Traditionally, AML classification and risk stratification relied on cytogenetic studies; however, molecular detection of gene mutations is playing an increasingly important role in classification, risk stratification, and management of AML. Molecular testing does not ...
To integrate genetic, physical, and cytological perspectives of the Sorghum bicolor genome, we selected 40 landed bacterial artificial chromosome (BAC) clones that contain different linkage map markers, 21 from linkage group 2 (LG-02) and 19 from linkage group 8 (LG-08). Multi-BAC probe cocktails were constructed for each chromosome from the landed BACs, which were also preevaluated for FISH si...
BACKGROUND Most sporadic colorectal cancer (sCRC) deaths are caused by metastatic dissemination of the primary tumor. New advances in genetic profiling of sCRC suggest that the primary tumor may contain a cell population with metastatic potential. Here we compare the cytogenetic profile of primary tumors from liver metastatic versus non-metastatic sCRC. METHODOLOGY/PRINCIPAL FINDINGS We prosp...
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