AIM Earlier studies have demonstrated that Bacopa monniera (BM), a plant described in Ayurveda for many CNS actions was found to exhibit antidepressant (methanolic extract at 20mg/kg and 40mg/kg p.o.) as well as antinociceptive activity (aqueous extract (AE) at 80 mg/kg, 120 mg/kg and 160 mg/kg p.o.). The present study sought to explore the possible mechanisms of antinociceptive effects of aque...

The purpose of this project is the investigation of LHRHa2 integrated effect with carp pituitary extract (CPE) in three stages injection on sexual indexes (fecundity, fertilization, hatch and larval survival) in artificial propagation of Barbusxanthopterus. 20 fish were divided in to 4 treatment and injected interpritoneal as follows 4mgkg-1b.w.of CPE as positive control, 4 µg/kg +4 mgkg-1b.w. ...

the purpose of this project is the investigation of lhrha2 integrated effect with carp pituitary extract (cpe) in three stages injection on sexual indexes (fecundity, fertilization, hatch and larval survival) in artificial propagation of barbusxanthopterus. 20 fish were divided in to 4 treatment and injected interpritoneal as follows 4mgkg-1b.w.of cpe as positive control, 4 µg/kg +4 mgkg-1b.w. ...

OBJECTIVE Sorafenib is a recommended treatment for advanced hepatocellular carcinoma. The study is to evaluate the efficacy of sorafenib plus cyproheptadine compared with sorafenib alone in patients with advanced hepatocellular carcinoma. METHODS A retrospective cohort study reviewed all consecutive advanced hepatocellular carcinoma cases with Child-Pugh Class A disease starting sorafenib tre...

Functional gastrointestinal disorders (FGIDs) negatively affect children's quality of life and health care costs. It has been proposed that alteration of gut serotonin leads to gastrointestinal dysmotility, visceral hypersensitivity, altered gastrointestinal secretions, and brain-gut dysfunction. Cyproheptadine, a serotonin antagonist, has been shown to be a potentially effective and safe treat...

OBJECTIVE Losing weight in consequence of appetite loss can be a sign of a serious underlying condition. Currently, the most widely prescribed medication for anorexia is cyproheptadine hydrochloride. However, the clinical use of cyproheptadine hydrochloride is limited by its side effects. In Iranian traditional medicine, Coriandrum sativum stimulates the appetite. Therefore, the effect of Coria...