Cyclopamine, a steroidal alkaloid from Veratrum californicum, is teratogenic causing a range of birth defects including cyclopia (synophthalmia) as well as other craniofacial and structural malformations. Previous studies have indicated that fetuses with cyclopia are smaller, under developed, and appear premature compared to gestational matched normal fetuses. Preliminary observations suggest t...

Rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia) are popular tisanes in their native South Africa and have a growing worldwide market. Both herbal teas are used traditionally for medicinal purposes and are rich in polyphenols with rooibos a rare source of the dietary dihydrochalcones, aspalathin and nothofagin. The principal polyphenols in honeybush include the xanthone mangife...

Phytochemical investigation of the whole plants of Crotalaria sessiliflora L. led to the isolation of four flavonoids. The structures of these compounds were identified as 2',4',5,7-tetrahydroxyisoflavone (1), 2',4',7-trihydroxyisoflavone (2), 4',7-dihydroxyflavone (3), and isovitexin (4) using spectroscopic analysis. Among these, compounds 2, and 3 have not been reported from Crotalaria specie...