BACKGROUND Cutaneous leishmaniasis is a chronic, infectious disease caused by protozoa of the genus leishmania. The incidence of this disease is high in Brazil, with 19,746 new cases having been detected in 2008. The presence of amastigotes in the cytoplasm of histiocytes constitutes diagnosis of the disease; however, their presence is rarely found in late lesions, making histological diagnosis...

Lobomycosis, also known as Jorge Lobo's disease, is a granulomatous, chronic fungal disease that involves the skin and subcutaneous tissue. The disease has been reported in South American, Central and North American countries, being particularly frequent in the Brazilian Amazon region. We report a case of disseminated lobomycosis in an 86 year-old Brazilian woman with a 55-year history of disse...

Granulomatous disorders include a wide variety of infectious and non-infectious conditions with heterogeneous clinical courses considerable constraints affected organs. We take cutaneous sarcoidosis as model disease to acquire new insights into the pathomechanisms granulomas. combined single-cell high-dimensional spatial transcriptomics fluorescently labeled antibody detection for protein expre...

BACKGROUND Granulomatous rosacea is considered a clinical variant of rosacea and is characterized by hard yellow, brown, red or flesh-colored cutaneous papules or nodules that may be severe and may lead to scarring. The lesions typically appear on the cheeks and periorificial lesions; they are monomorphic in each patient and sit on relatively normal-appearing skin. The diagnosis should be estab...

Abstract A variety of associations between cutaneous manifestations and myelodysplastic syndrome (MDS) have been described, but the frequency is unknown. The presence may therapeutic prognostic significance, as thereof has reported to be associated with poor prognosis or acute myeloid leukaemia (AML) progression, precede diagnosis MDS [Farah C, Bulai Livideanu Jegu J et al. Prevalence value in ...

Brucellosis is a chronic granulomatous zoonosis with protean manifestations. Cutaneous involvement in Brucellosis is a relatively rare phenomenon. We describe a case of Brucella melitensis infection presenting with erythema nodosum like skin lesions involving palms and soles in a 70 years old lady.

Acanthamoeba spp. are pathogenic protozoa that are uncommonly encountered. They tend to infect immunocompromised patients, most often causing cutaneous lesions and in some instances granulomatous amebic encephalitis, as well as rare instances of dissemination to other organs. We present a case of amebic osteomyelitis of the fibula in a patient with rejection of a transplanted kidney who was chr...

A 60-year-old immunocompetent lady with disseminated primary cutaneous histoplasmosis is reported. Histology showed a granulomatous skin infiltrate with numerous intracellular PAS positive rounded yeast cells within macrophages. Culture on Sabouraud's dextrose agar yielded a typical cottony white colony characteristic of Histoplasma capsulatum. Treatment with itraconazole showed an excellent re...

Patients with chronic granulomatous disease are predisposed to fungal infections and are therefore routinely prescribed antifungal prophylaxis. We report a case where acremonium was responsible for causing a cutaneous infection (mycetoma) despite antifungal prophylaxis. Treatment with voriconazole was initiated and the infection gradually resolved. This case highlights the need for careful clin...

The free-living amoeba (FLA) group of protozoa that can be found in various types conditions nature, one which is the genus Acanthamoeba. Although, number infections caused by this protozoan low, diagnosis was still difficult to confirm and therefore there were a higher mortality, especially those associated with encephalitis. This review presents some information about biology, pathogenesis, c...