Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and is triggered via abnormal accumulation of amyloid-β peptide (Aβ). Aggregated Aβ is responsible for disrupting calcium homeostasis, inducing neuroinflammation, and promoting neurodegeneration. In this study, we generated curcuminoid submicron particle (CSP), which reduce the average size to ~60 nm in diameter. CSP had ...

Four new 1,5-benzothiazepines were synthesized by reaction of o-aminothiophenol with curcumin and curcuminoid β-diketones, in methanol acetic acid. The mechanism involves a Michael addition on the CC double bond affording benzothiazepine two pendant groups, an aryl group adjacent to sulfur atom 1-phenylethanone NH seven membered ring. 1D 2D multinuclear NMR (1H, 13C, 15N, 119F) solution 13C 15N...

Curcuma longa commonly known as turmeric has been used in Indian Ayurvedic medicine as a constituent to treat various disorders. It is by now clear that principal curcuminoid of turmeric; curcumin, a yellow pigment, is responsible for these beneficiary activities. The aim of the present study was to evaluate anti-mycobacterial effect of curcumin (CMN) on intracellular growth of MDR clinical iso...

Calebin-A is a curcuminoid compound isolated from turmeric. Herein, we investigated the antiproliferative effect of calebin-A liposomes on cell growth compared with calebin-A. In this study, the calebin-A liposomes were successfully prepared by thin film-sonication method. The antiproliferative activity was evaluated in mouse neuroblastoma Neuro-2a cells and human SW480 colorectal tumor cells. ...