Abstract: Aim: The main aim of present study is to formulate cubosomes containing curcumin. Curcumin a BCS class IV drug which has clinically proven good anti-bacterial property. Materials and Methods: Cubic nanoparticles were prepared by hydrotrope dilution method. Cubosomes formulated with the glyceryl monooleate pluronic F-127 as lipid surfactant respectively, obtained formulations character...

The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...

Automotive emission is becoming a critical threat to today’s human health. Many researchers are studying engine designs leading to less fuel consumption. Gearbox selection plays a key role in an engine design. In this study, Taguchi quality engineering method is employed, and optimum gear ratios in a five speed gear box is obtained. A table of various gear ratios is suggested by design o...

parametric design optimization of an automotive body crashworthiness improvement is presented. the thicknesses of parts are employed as design variables for optimization whose objective is to increase the maximum deceleration value of the vehicle center of gravity during an impact. using the taguchi method, this study analyzes the optimum conditions for design objectives and the impact factors ...

The herbal medicine Ipomoea stolonifera (I. stolonifera) has previously been shown to have considerable anti-inflammatory potential in vivo and in vitro. To establish a method for exploring the synergistic effects of multiple compounds, we study the compatibility and dose optimization of compounds isolated from n-butanol extract of I. stolonifera (BE-IS). Raw264.7 cell was treated with lipopoly...

Curcumin, the yellow pigment in turmeric and curry, has antioxidative and anticarcinogenic activities. In this study, we investigated the pharmacokinetic properties of curcumin in mice. After i.p. administration of curcumin (0.1 g/kg) to mice, about 2.25 microg/ml of curcumin appeared in the plasma in the first 15 min. One hour after administration, the levels of curcumin in the intestines, spl...