Purpose Excessive production of parathyroid hormone-related protein (PTHrP) by tumor-like synoviocytes contributes to joint destruction in rheumatoid arthritis (RA). Having previously demonstrated that curcuminoid-only and essential oil-only fractions of turmeric prevent joint destruction in an animal model of RA, we hypothesized that synoviocyte PTHrP production could be one signaling pathway ...

Introduction: Since Curcuma longa extract and curcumin have been shown to be potent antioxidant agents, they were used in cultured adult mouse spinal cord slices to investigate whether they can inhibit apoptosis in motor neurons. Methods: Slices from the thoracic region of adult mice spinal cord were divided into four groups: 1. Freshlyprepared slices (time 0) 2. Control 3. Slices treated by cu...

introduction: the aim of the study was to investigate the effects of curcuma longa (c. longa) extract on adriamycin-induced hepatotoxicity in rat. methods: animals were divided in six groups: control (co), adriamycin (adr), adriamycin with vitamin c (adr+vitc), vitamin c (vit c), c. longa with adriamycin (cl+adr) and without adriamycin (cl-adr). hepatotoxicity was induced by adriamycin 5mg/kg a...

abstract:turmeric is a member of the ginger family (zingiberaceae), which is extensively used as a spice, food preservative and colouring material. curcumin is a main bioactive natural compound derived from the rhizome of this plant. curcumin can exist in several tautomeric forms, keto and enol. the keto form is more stable than enol form. silyl ethers have proven to be versatile substrates for...

Chaeridiona mayuri n. sp. infesting ginger (Zingiber officinale Roscoe) and turmeric (Curcuma longa L.) in southern India is described and illustrated. Cheilocostus speciosus ( J. Koenig) C. D. Specht, Globba sessiliflora Sims and Zingiber zerumbet (L.) Smith are reported as additional host plants. Chaeridiona pseudometallica Basu is redescribed and illustrated. A key to the species of Indian C...

An UPLC-UV-MS method was developed for the determination of curcuminoids and ar-turmerone from roots of Curcuma longa L., different species of Curcuma (C. zedoaria, C. phaecaulis, C. wenyujin and C. kwangsiensis) and dietary supplements that claimed to contain C. longa. The separation was achieved within 3.5 minutes using a C-18 column, a water/acetonitrile mobile phase, containing formic acid ...

Introduction: The aim of the study was to investigate the effects of Curcuma longa (C. longa) extract on Adriamycin-induced hepatotoxicity in rat. Methods: Animals were divided in six groups: Control (CO), Adriamycin (ADR), Adriamycin with Vitamin C (ADR+VitC), Vitamin C (Vit C), C. longa with Adriamycin (CL+ADR) and without Adriamycin (CL-ADR). Hepatotoxicity was induced by Adriamycin 5mg/kg a...

Diabetes mellitus is the most common metabolic disorder affecting millions worldwide. It is recognized as a global major health problem [1]. As alternatives to the available orthodox medicines, plants are considered a potential source for the treatment of diabetes within traditional ethnomedicine practices. Literature surveys summarize the benefit of several ethnobotanicals as anti-diabetic age...

Osteoarthritis (OA) is a chronic inflammatory degenerative process that affects joints such as the hands, hips, shoulders, feet, spine, and especially knees in millions of people worldwide. Some authors have shown that Curcuma longa components may exhibit benefic effects in the treatment of degenerative diseases as OA. This plant belongs to the family Zingiberaceae and it is popularly known as ...

Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H (37)Rv strain at 200 microg/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 microg/mL. H (37)Rv:Mycobacterium tuberculosis H (37)Rv strai...