A recently reported mRNA, encoding 'carbonic anhydrase-related polypeptide' (CARP) from the Purkinje cells of mouse cerebellum, was shown to have a 30-40% deduced amino acid sequence identity with the carbonic anhydrases (CA) of mammals. In order to compare the mouse and human CARP sequences, we used the polymerase chain reaction (PCR) to amplify human CARP sequences from several cDNA libraries...

INTRODUCTION In rheumatoid arthritis (RA), several genetic risk factors and smoking are strongly associated with the presence of anticitrullinated protein antibodies (ACPA), while much less is known about risk factors for ACPA-negative RA. Antibodies against carbamylated proteins (anti-CarP) have been described in both ACPA-positive and ACPA-negative RA patients. In this study, we have analysed...

The technique of representational difference analysis of cDNA has been applied to screen for differentially expressed genes in a canine model of pacing-induced heart failure. We identified the canine homolog of the cardiac ankyrin repeat protein (CARP) which has been shown to be involved in the regulation of the transcription of cardiac genes. To confirm the significance for human heart failure...

Transforming growth factor1 (TGF1) is a potent regulatory cytokine with pleiotropic effects on the immune system. To examine the role of TGF1 in fish immunity, the full-length cDNA of grass carp TGF1 was isolated from grass carp spleen. The open reading frame of grass carp TGF1, 1134 bp in length, encodes a 377 amino acid protein. Tissue distribution study by RT-PCR showed TGF1 mRNA was predomi...

Fishes show a remarkable diversity of shapes which have been associated with their swimming abilities and anti-predator adaptations. The crucian carp (Carassius carassius) provides an extreme example of phenotypic plasticity in body shape which makes it a unique model organism for evaluating the relationship between body form and function in fishes. In crucian carp, a deep body is induced by th...

A massive release of artificial radionuclides from the Fukushima Dai-ichi Nuclear Power Plant caused radioactive contamination of farms as well as of aquatic products. Carp in small ponds in the highly radiocontaminated area of Iitate Village, Fukushima Prefecture, have been confined to the ponds since the accident, and it is thought that the carp may have suffered health issues as a result. Th...

Given an undirected graph with edge costs and edge demands, the Capacitated Arc Routing problem (CARP) asks for minimum-cost routes for equal-capacity vehicles so as to satisfy all demands. Constant-factor polynomial-time approximation algorithms were proposed for CARP with triangle inequality, while CARP was claimed to be NP-hard to approximate within any constant factor in general. Correcting...

OBJECTIVE Good biomarkers are important to guide decisions in the clinical management of rheumatoid arthritis (RA). RA patients harbor antibodies directed against carbamylated proteins which may predict joint damage. This study investigated whether antibodies against carbamylated proteins (anti-CarP) may serve as surrogate prognostic markers. MATERIAL AND METHODS Fifty-three patients with a d...

This paper highlights the present status and genetic improvement strategies for endemic and exotic carp species of Bangladesh, including future plans. In this country, both major and minor endemic and exotic (introduced) carps are the key species for aquaculture, particularly for polyculture. There are at least 13 endemic species of carps: among them 4 major carps (catla, rohu, mrigal and calba...

CARP-CG is a conjugate gradient (CG) acceleration of CARP, which was introduced by Gordon and Gordon as a robust block-parallel scheme for sparse linear systems. CARP performs Kaczmarz (KACZ) row projections within the blocks, and the results from the separate blocks are merged by averaging, for each component, its updated values from the different blocks. The averaging operations are equivalen...