نتایج جستجو برای: cufe2o4si imid pmo

تعداد نتایج: 823  

2014
Taavi Lehto Alejandra Castillo Alvarez Sarah Gauck Michael J. Gait Thibault Coursindel Matthew J. A. Wood Bernard Lebleu Prisca Boisguerin

Cell-penetrating peptide-mediated delivery of phosphorodiamidate morpholino oligomers (PMOs) has shown great promise for exon-skipping therapy of Duchenne Muscular Dystrophy (DMD). Pip6a-PMO, a recently developed conjugate, is particularly efficient in a murine DMD model, although mechanisms responsible for its increased biological activity have not been studied. Here, we evaluate the cellular ...

Journal: :Bioinformatics 2012
Sentil Balaji Charles Mcclendon Rajesh Chowdhary Jun S. Liu Jinfeng Zhang

MOTIVATION Molecular interaction information, such as protein-protein interactions and protein-small molecule interactions, is indispensable for understanding the mechanism of biological processes and discovering treatments for diseases. Many databases have been built by manual annotation of literature to organize such information into structured form. However, most databases focus on only one ...

M. Masteri-Farahani, R. Kamrani

A new hybrid nanomaterial was developed by immobilization of phosphomolybdate anions on the surface of modified magnetite nanoparticles with quaternary phosphonium cations. Silica coated magnetic nanoparticles supported phosphonium cations, Ph3P+-SCMNPs, were prepared by covalent attachment of chloropropylsilyl groups on the surface of silica coated magnetite nanoparticles...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2002
Vikram Arora Melissa L Cate Chandramallika Ghosh Patrick L Iversen

Antisense phosphorodiamidate morpholino oligomers (PMO) inhibit targeted gene expression by preventing ribosomal assembly, thus preventing translation. Inhibition of cytochrome P450 (P450) 3A4 expression was examined in primary human hepatocytes from 11 donors and in Caco-2 cells (stably transfected with CYP3A4 cDNA on an extrachromosomal vector) by evaluating the metabolism of substrate 7-benz...

2017
Xia Wang Indre Thiel Alexey Fedorov Christophe Copéret Victor Mougel Marc Fontecave

Well-defined and fully characterized supported CO2 reduction catalysts are developed through the immobilization of an earth abundant Mn complex on bpy-PMO (bpy 1⁄4 bipyridine; PMO 1⁄4 Periodic Mesoporous Organosilica) platform materials. The resulting isolated Mn-carbonyl centers coordinated to bipyridine functionalities of bpy-PMO catalyze the photoreduction of CO2 into CO and HCOOH with up to...

2015
Hui-Fang Liu Hong-Chen He Lin Yang Zhou-Yuan Yang Ke Yao Yuan-Chao Wu Xi-Biao Yang Cheng-Qi He

BACKGROUND Osteoporosis (OP) and osteoarthritis (OA) are prevalent skeletal disorders among postmenopausal women. Coexistence is common especially that of postmenopausal osteoporosis (PMO) and lumbar OA. An hypothesis has been raised that OP and OA might share the same pathogenic mechanism, and pulsed electromagnetic fields (PEMFs) were reported to have anti-osteoporosis and anti-osteoarthritis...

2017
Mihail Boyanov Alexander Shinkov Emi Psachoulia Michele Intorcia Reneta Petkova

BACKGROUND Postmenopausal osteoporosis (PMO) is common among women over 50 years of age and is associated with an increased risk of fracture. Bone-targeted agents, such as denosumab, can reduce fracture risk in patients with PMO. OBJECTIVE The aim was to describe baseline characteristics and changes in bone mineral density (BMD) T-scores among women with PMO receiving denosumab in Bulgaria. ...

2012
Corinne Betts Amer F Saleh Andrey A Arzumanov Suzan M Hammond Caroline Godfrey Thibault Coursindel Michael J Gait Matthew JA Wood

Antisense oligonucleotides (AOs) are currently the most promising therapeutic intervention for Duchenne muscular dystrophy (DMD). AOs modulate dystrophin pre-mRNA splicing, thereby specifically restoring the dystrophin reading frame and generating a truncated but semifunctional dystrophin protein. Challenges in the development of this approach are the relatively poor systemic AO delivery and in...

Journal: :The European respiratory journal 1998
J O Maillard L Burdet G van Melle J W Fitting

Twitch mouth pressure (Pmo,tw) during magnetic phrenic nerve stimulation and sniff nasal inspiratory pressure (SNIP) were recently proposed as alternative noninvasive methods for assessing inspiratory muscle strength. This study aimed to compare their reproducibility with maximal inspiratory pressure (MIP) in normal subjects. Ten healthy subjects were studied at functional residual capacity in ...

Journal: :Journal of virology 2005
Tia S Deas Iwona Binduga-Gajewska Mark Tilgner Ping Ren David A Stein Hong M Moulton Patrick L Iversen Elizabeth B Kauffman Laura D Kramer Pei-Yong Shi

RNA elements within flavivirus genomes are potential targets for antiviral therapy. A panel of phosphorodiamidate morpholino oligomers (PMOs), whose sequences are complementary to RNA elements located in the 5'- and 3'-termini of the West Nile (WN) virus genome, were designed to anneal to important cis-acting elements and potentially to inhibit WN infection. A novel Arg-rich peptide was conjuga...

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