Aromatase inhibitors (AI) profoundly suppress estrogen levels in postmenopausal women and are effective in breast cancer prevention among high-risk postmenopausal women. Unfortunately, AI treatment is associated with undesirable side effects that limit patient acceptance for primary prevention of breast cancer. A double-blind, randomized trial was conducted to determine whether low and intermit...

The purpose of this study was to report the characteristics of an equivalent quality unflattened (eqUF) photon beam in clinical implementation and to provide a generalized method to describe unflattened (UF) photon beam profiles. An unflattened photon beam with a beam quality equivalent to the corresponding flat 6 MV photon beam (WF) was obtained by removing the flattening filter from a Siemens...

Dose profiles produced by wedge filters in the non-wedged direction can exhibit a 7% or greater dose reduction at the outer ends of the field compared with open field profiles. However, many planning systems use open field profiles to model wedged dose distributions. In the present work, wedges have been modified to reproduce open field profile shapes. This modification involved removing varyin...

objective: the anxiety profile in the stimulant-sensitized animals is not clear. thus, this study was conducted to elucidate the effects of acute and chronic administration of methamphetamine (meth) on the anxiety profile. the aim of this study was to examine whether meth-sensitized rats would show an increase in the expression of anxiogenic-like behaviors and to determine whether a low dose of...

Dose distributions for photon beam were measured using a Photo-Stimulated Luminescence Dosimeter (PSLD) sheet, which has 18 x 24 cm dimension and 0.2 mm thickness. Its density and effective atomic number are 1.0 g/cm and 7.6, respectively. The read out was performed by blue LED lights for 20 seconds, which was much shorter than the readout time for TLD. The percent depth dose and dose profile w...

PURPOSE Combination estrogen + progestin therapy has been associated with increased breast cancer risk in postmenopausal women. Selective estrogen receptor modulators (SERM) are potential alternatives to progestins, although the endometrial safety of estrogen + SERM co-therapies is not known. The goal of this study was to evaluate the endometrial profile of low-dose estradiol and the SERM tamox...

The biological equivalent dose profile of the pion beam was predicted with one parameter (gamma) using physical dose and pion star density. The value of the relative biological effectiveness (RBE) at each depth was given as a linear function of pion star density (PSD): RBE = 1.0 + gamma PSD, assuming (i) the mixed beam lesion additivity model and (ii) the linear relationship between the ratio o...

The study investigates the therapeutic value of Lagerstroemia speciosa ethanolic green and red leaf extracts against Lauric acid (LA) a Ketogenic diet (KGD) in Albino rats. is an important constituent breast milk, forming nutritional factors having various medicinal values. It present 6.2% human 3.1% goat 2.9% cow milk. also found plant sources like coconut, cohune, palm kernel oil. uses fat, p...

BACKGROUND While aspirin is a well-established and generally effective anti-platelet agent, considerable inter-individual variation in drug response exists, for which mechanisms are not completely understood. Metabolomics allows for extensive measurement of small molecules in biological samples, enabling detailed mapping of pathways involved in drug response. METHODS AND RESULTS We used a mas...