A major impediment to improving the health of communities is the lack of qualified clinical and translational research (CTR) investigators. To address this workforce shortage, the National Institutes of Health (NIH) developed mechanisms to enhance the career development of CTR physician, PhD, and other doctoral junior faculty scientists including the CTR-focused K12 program and, subsequently, t...

The calcitonin (CT) receptor (CTR) and the CTR-like receptor (CRLR) are close relatives within the type II family of G-protein-coupled receptors, demonstrating sequence identity of 50%. Unlike the interaction between CT and CTR, receptors for the related hormones and neuropeptides amylin, CT-gene-related peptide (CGRP) and adrenomedullin (AM) require one of three accessory receptor-activity-mod...

conclusion the cv value correlated more closely with low lvef and more accurately indicated an enlarged heart than ca or ctr. this may be due to the fact that an anteroposterior measurement of heart size is included in the former but not the latter two measurements. these study results may help quantify left heart enlargement with greater accuracy than may be obtained from standard cxr. backgro...

BACKGROUND The aim f this study was to evaluate the effect of capsular tension ring implantation during cataract surgery on the incidence of neodymium: YAG (Nd: YAG) laser posterior capsulotomy in myopic (axial length [AL] ≥25.00 mm) eyes. MATERIAL/METHODS In this retrospective study, the records of the cases of 117 myopic patients who underwent cataract surgery between January 2004 and January...

objective: although key roles for dietary vitamin e (vite) and fatty acid (fa) in fertility have been confirmed, limited data are available on the effects of vite alone, or a constant level of vite supplemented by dietary omega-6 and omega-3 fas in combination on male reproduction. consequently in this paper, the effects of vite, sunflower oil, fish oil and their combination on rat sperm were i...

Abstract In recent years, the widespread use of drones for transport people and cargo in between cities has become increasingly considered. From point view airspace organization, world capitals with high potential this operation mostly have one common parameter - airspaces defined as controlled zones are established above them, an integral part around large international airports. Given current...

Frataxin (FXN) is an α/β protein that plays an essential role in iron homeostasis. Apparently, the function of human FXN (hFXN) depends on the cooperative formation of crucial interactions between helix α1, helix α2, and the C-terminal region (CTR) of the protein. In this work we quantitatively explore these relationships using a purified recombinant fragment hFXN90-195. This variant shows the ...

Purpose. We have observed worsening thumb pain following carpal tunnel release (CTR) in some patients. Our purpose was to determine the effect of open CTR on thumb carpometacarpal (CMC) biomechanics. Methods. Five fresh-frozen cadaver arms with intact soft tissues were used. Each specimen was secured to a jig which fixed the forearm at 45° supination, and the wrist at 20° dorsiflexion, with thu...

Perinatal maternal separation stress (PMSS) causes brain deficits that last through ageing. Choline is essential for brain development. Alternately, Clitorea ternatea aqueous root extract (CTR) is proved to enhance neural plasticity in rat hippocampus. The present study is designed to elucidate the comparative efficacy of choline and CTR in attenuating PMSS induced neural cell deficits in CA1, ...

Members of the copper uptake transporter (CTR) family from yeast, plants, and mammals including human are required for cellular uptake of the essential metal copper. Based on biochemical data, CTRs have three transmembrane domains and have been shown to oligomerize in the membrane. Among individual members of the family, there is little amino acid sequence identity, raising questions as to how ...