نتایج جستجو برای: csf gene

تعداد نتایج: 1165569  

Journal: :Molecular and cellular biology 1995
K J Stacey L F Fowles M S Colman M C Ostrowski D A Hume

The mouse urokinase-type plasminogen activator (uPA) gene was used as a model macrophage colony-stimulating factor 1 (CSF-1)-inducible gene to investigate CSF-1 signalling pathways. Nuclear run-on analysis showed that induction of uPA mRNA by CSF-1 and phorbol myristate acetate (PMA) was at the transcriptional level in bone marrow-derived macrophages. CSF-1 and PMA synergized strongly in the in...

2014
Alexandre Henriques Stefan Kastner Eva Chatzikonstantinou Claudia Pitzer Christian Plaas Friederike Kirsch Oliver Wafzig Carola Krüger Robert Spoelgen Jose-Luis Gonzalez De Aguilar Norbert Gretz Armin Schneider

BACKGROUND Amyotrophic lateral sclerosis (ALS) is an incurable fatal motoneuron disease with a lifetime risk of approximately 1:400. It is characterized by progressive weakness, muscle wasting, and death ensuing 3-5 years after diagnosis. Granulocyte-colony stimulating factor (G-CSF) is a drug candidate for ALS, with evidence for efficacy from animal studies and interesting data from pilot clin...

Journal: :Blood 1995
C H Chan B R Blazar C R Eide R J Kreitman D A Vallera

A fusion protein was synthesized consisting of the murine granulocyte-macrophage colony-stimulating factor (mGM-CSF) gene spliced to a truncated form of the diphtheria toxin (DT390) gene coding for a molecule that retained full enzymatic activity, but excluded the native binding domain. The DT390-mGM-CSF hybrid gene was cloned into a vector under the control of an inducible promoter and the pro...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1985
M A Cantrell D Anderson D P Cerretti V Price K McKereghan R J Tushinski D Y Mochizuki A Larsen K Grabstein S Gillis

Human granulocyte/macrophage colony-stimulating factor (GM-CSF) is a glycoprotein that is essential for the in vitro proliferation and differentiation of precursor cells into mature granulocytes and macrophages. In this report we have used a mouse GM-CSF cDNA clone to isolate human GM-CSF clones from libraries made from HUT-102 messenger RNA and mitogen-stimulated T-lymphocyte messenger RNA. Th...

Journal: :Seizure 2008
Silvio Basic Sanja Hajnsek Nada Bozina Igor Filipcic Davor Sporis Damir Mislov Ana Posavec

BACKGROUND Epilepsy is refractory to medical treatment in about one-third of the patients. The exact pathological mechanism of epilepsy pharmacoresistance is still unclear, but a decreased antiepileptic drug (AED) uptake into the brain is suspected to play a role. P-glycoprotein (Pgp), a transmembrane transporter encoded by ABCB1 gene and located at the endothelial cells of the blood-brain barr...

Journal: :International journal of oncology 2007
Toshiyasu Ojima Makoto Iwahashi Masaki Nakamura Kenji Matsuda Mikihito Nakamori Kentaro Ueda Teiji Naka Masahiro Katsuda Motoki Miyazawa Hiroki Yamaue

Granulocyte macrophage colony-stimulating factor (GM-CSF) is a key cytokine for the generation and stimulation of dendritic cells (DCs), and it may also play a pivotal role in promoting the survival of DCs. In this study, the feasibility of creating a cancer vaccine using DCs adenovirally transduced with the carcinoembryonic antigen (CEA) gene and the GM-CSF gene was examined. In addition, the ...

Journal: :Blood 1994
Y Suen S M Lee J Schreurs E Knoppel M S Cairo

We have previously shown that protein production and mRNA expression of granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), and interleukin-3 are decreased in stimulated mononuclear cells (MNCs) from human umbilical cord compared with adult peripheral blood. These deficiencies may contribute to the increased susceptibility of neonates to inf...

Journal: :The Journal of Experimental Medicine 1991
M P Colombo G Ferrari A Stoppacciaro M Parenza M Rodolfo F Mavilio G Parmiani

We have investigated the effect of granulocyte colony-stimulating factor (G-CSF) delivery at the site of tumor growth by transducing, via retroviral vector, the human (hu) G-CSF gene into the colon adenocarcinoma C-26 and assaying the ability of transduced cells to form tumors when injected into syngeneic mice. As a control, the same tumor cells were infected with retroviruses engineered to tra...

Journal: :Journal of leukocyte biology 2006
Takahisa Shimizu Lisa Esaki Hiroko Mizuno Ken Takeda

We reported previously that treatment of human myeloblastic leukemia ML-1 cells with all-trans retinoic acid (ATRA) in combination with GM-CSF enhances the granulocytic differentiation, which is induced only slightly by ATRA alone. To investigate the mechanism underlying this differentiation and the synergistic effect of ATRA and GM-CSF, we used cDNA microarray to examine gene expression profil...

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