The prevalence of cryptorchidism has increased over the past decades, yet its origins remain poorly understood. Testis descent is dependent on androgens and likely affected by endocrine disrupting compounds (EDCs), targeting androgen receptor (AR). We investigated association between anti-androgenic activity, not derived from natural hormones, in maternal breast milk impaired testis among boys....

Objective- Perturbation of the normal process of testicular descent results in the condition of cryptorchidism. Spermatogenesis is generally impaired in cryptorchid testes because of high intratesticular temperature. It seems that the main mechanisms underlying the process of spermatozoa demise is apoptosis by overgeneration of free radicals. So, the aim of the present study was to investigate ...

OBJECTIVE To clarify the role of peritoneography in assessing the patency of processus vaginalis (PV) in pediatric patients diagnosed with cryptorchidism. MATERIALS AND METHODS We designed a prospective clinical trial to evaluate the patency of PV in boys presenting cryptorchidism. Herniography was performed in 310 prepubertal boys. Data about the morphology of PV was compared with operative ...

Persistent Mullerian Duct Syndrome (PMDS) is characteristically associated with unilateral or bilateral cryptoorchidism. Like other undescended testis, these gonads are at an increased risk of malignant transformation. We report a case of intra abdominal seminoma in cryptorchid testis of a patient with the Persistent Mullerian Duct Syndrome, hitherto uncommonly reported in India.

BACKGROUND Cryptorchidism is a frequent syndrome occurring in 1-2% of males within the first year of age. Autoimmune reactions, particularly directed to testicular elements and/or spermatozoa have been found to be often associated with cryptorchidism. Therefore we investigated in this study the frequency of HLA class II alleles in order to recognize possible genetic predisposition for antisperm...

Cryptorchidism is not a single disease; it apparently results from failure of one of at least two functions involving products of Leydig cells. Cryptorchidism is symptomatic of underlying testis dysgenesis. Precise terminology is important to distinguish and understand three phases of testis descent. Abdominal translocation involves holding a testis near the internal inguinal ring plus slight d...

Of the 10,730 neonates born in the period 1978-1997 and examined for cryptorchidism (C) at birth, 1387 were pre-term (gestational age <37 wk), and 9343 were full-term. At birth, a total of 737 neonates (6.9%) were cryptorchid, 487 had bilateral C and 250 unilateral C. The C rate of pre-terms was 10 times higher than that of the full-terms (30.1 and 3.4%, respectively). Comparing the two studied...