The ability of croton oil to elicit epithelial tu mors in mice in areas previously treated with subcarcinogenic amounts of carcinogenic hydrocar bons is a well documented fact. In the typical ex periment tumors are initiated in the skin of mice by the single application of a solution of some car cinogenic hydrocarbon at a level that induces few if any tumors. The repeated application of croton ...

Croton (Codiaeum variegatum) with its amazing colors and leathery leaves is regarded as a beautiful foliage plant. The plant is native of South East Asia. Generally crotons are multiplied vegetatively by means of cuttings and air layering. This process is slow in response and need to maintain large number of mother plants stock. Micropropagation is an alternative mean of propagation that can me...

A new triterpenoid saponin, loniceroside C was isolated from the aerial parts of Lonicera japonica. Its structure was established to be 3-O-beta-D-glucopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl (1-->2)-[beta-D-xylopyranosyl(1-->6)]-beta-D-glucopyranosyl ester by spectroscopic techniques and chemical transformations. Loniceroside C showed in vivo antiinflammatory activity against mouse ...

In a previous communication (5), the author has shown that when the effective carcinogenic potency of 3,4-benzpyrene for the mouse's skin was reduced by application of the hydrocarbon in a dilution ot~ o.o 5 per cent, the low tumor yield (o to 6 per cent at the 2oth week) was increased to 80 per cent by application of croton resin concurrently with the benzpyrene. 1 This augmentation of carcino...

Croton é um gênero de Euphorbiaceae com cerca de 1300 espécies, amplamente distribuídas em regiões tropicais do Novo e Velho Mundos. Várias espécies há muito tempo desempenham papel importante nos usos tradicionais de plantas medicinais na África, Ásia e América do Sul. Tais usos incluem tratamento de câncer, constipação intestinal, diarréia e outros problemas digestivos, diabetes, feridas exte...

The importance of DNA synthesis in the initiation of skin tumorigenesis by urethan was investigated. Treatment of mice with 0.5% croton oil increases the rate of epidermal DNA synthesis 3to 6-fold beginning at 9 to 12 hr, reaching a peak at 18to 24 hr, and remaining elevated for 3 to 4 days. Croton oil treatment times of -24, -6, +1, and +24 hr were tested for their effect on initiation of skin...

In a previous communication (5), the author has shown that when the effective carcinogenic potency of 3,4-benzpyrene for the mouse's skin was reduced by application of the hydrocarbon in a dilution ot~ o.o 5 per cent, the low tumor yield (o to 6 per cent at the 2oth week) was increased to 80 per cent by application of croton resin concurrently with the benzpyrene. 1 This augmentation of carcino...

brought to visible tumors. Mottram (10) observed tumor production in mouse skin after exposing it to a single treatment with a carcinogenic hydrocarbon, followed by re peated applications of croton oil. Later, Berenblum and Shubik (3) adapted this method to a quantitative approach to the study of chemical carcinogenesis. According to this method, the actual number of tumors produced were said t...