difficulty in swallowing (dysphagia) is common among all age groups, especially in elderly and children. orally disintegrating tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quicksetof action. the purpose of this study was to formulate and evaluate an orally disintegrating tablet (odt) containing captopril while using croscarmellose sodium,...

RZT is potent anti migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B and 5-HT 1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid action, which is required for immediate relief from migraine pain. Marketed freeze dried tablet of RZT is available. Freeze drying is cumbersome and it yields a ...

With the aim of directly predicting the functionality and mechanism of disintegrants during the disintegration and dissolution of tablets, we investigated an analysis method based on available surface area, which is the surface area of a drug in a formulation in direct contact with the external solvent during dissolution. We evaluated the following disintegrants in this study: sodium starch gly...

In the present work, fast dissolving tablets of clonazepam were prepared by direct compression method with a view to enhance patient compliance. Three super-disintegrants, viz., crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios with microcrystalline cellulose (Avicel PH-102) along with directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The...

Objective: The present study was aimed to prepare and evaluate Donepezil HCl Orodispersible tablets (DO-ODTs) using natural synthetic superdisintegrants increase patient compliance. Methods: Direct compression adapted crospovidone, croscarmellose sodium as mucilage isolated from fruits of Abelmoschus esculentus at different concentrations along with microcrystalline cellulose aerosil. powder mi...

The objective of this study was to investigate the swelling characteristics of various swellable polymers in swelling layers that induce the rupturing of an outer polymer coating in pulsatile drug delivery systems (DDS). An apparatus was designed to measure simultaneously the swelling energy/force and water uptake of discs, made of polymers. The swelling energy of several excipients decreased i...

This study was concerned with the investigation of acute pharmacological responses (pharmacodynamics) including analgesic and anti-inflammatory effects of ketorolac tromethamine fast dissolving tablets prepared by direct compression method using 3% croscarmellose sodium as a superdisintegrant by applying tail flick test and carragenan induced rat paw edema test respectively. Also, the work aime...

The hydrophobicity of poorly soluble drugs can delay tablets disintegration. We probed here the influence different disintegrants on disintegration challenging hydrophobic formulations. Tablets containing diluents, hydrogenated vegetable oil and either sodium starch glycolate (SSG), croscarmellose (CCS) or crospovidone (XPVP) were prepared. time was tested immediately after storage at 40 °C 75%...

Pantoprazole is a potent and selective proton pump inhibitor. It is an effective agent in the treatment of Peptic ulcers, Gastro-oesophageal reflux disease (GERD), Oesophagitis, Zollinger-Ellison syndrome and other GI hypersecretory disorders. It provides rapid symptoms relief up to 85-90% of Ulcer patients within 1 hour of treatment. It has mediocre bioavailability of 50% and poor aqueous solu...