background and aims. despite available evidence for the role of herpes viruses in destructive periodontal diseases, no cause-and-effect relationship has been found to date. this study compared the titer of immunoglobulin g (igg), immunoglobulin m (igm) against human cytomegalovirus (hcmv) in gingival crevicular fluid between individuals with periodontitis and with healthy periodontium. material...

background: this study compared the effect of adjunctive low dose doxycycline and licorice on gingival crevicular fluid (gcf) matrix metalloproteinase-8 (mmp-8) levels in patients with chronic periodontitis. materials and methods: in this in vivo , experimental study 39 patients with mild to moderate chronic periodontitis were selected. samples of gcf were collected from three deepest pockets a...

OBJECTIVE Interleukin-1β (IL-1β) is one of the most important cytokines which seems to have an important role in the inflammatory process in gingival and peri-implant tissues. The aim of this split-mouth study was to investigate the relationship between the concentration of IL-1β in gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) and clinical parameters such as plaque i...

Hepatocyte growth factor (HGF) production by oral fibroblasts is enhanced by various molecules that are induced during inflammatory conditions including periodontitis. HGF plays an important role in the progression of periodontitis, by stimulating intense growth of epithelial cells and preventing regeneration of connective tissue attachments. Smokers have a greater risk factor in the pathogenes...

Periodontitis is a low-grade inflammatory disease caused by subgingival dysbiotic microbiota. Multiple studies have determined the higher prevalence of tooth loss and poor oral hygiene in patients with Alzheimer’s (AD). However, periodontal diagnosis, bacteria or mediators has not been measured to date. Aim: To determine status, pro-inflammatory mediators, Porphyromonas gingivalis load, Apolipo...