PVCre mice--> combined with AAV-FLEX vectors allowed efficient and specific targeting of PV+ interneurons in the striatum. However, diffusion viral particles to globus pallidus caused massive transduction projection neurons subsequent anterograde transport transgene product subthalamic nucleus substantia nigra pars reticulata. Different AAV serotypes (1 9) promoters (CBA human synapsin) were ev...

Background and Objective: The purpose of this study was to investigate the preconditioning effect of aerobic exercise with vitamin D3 consumption on vascular endothelial growth factor (VEGF) level in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson’s disease. Materials and Methods: Forty-eight male rats weighing 250-300 g were randomly assigned to 6 groups: healthy control, Parkin...

BACKGROUND Alterations in the dopaminergic reward system, predominantly the striatum, constitute core characteristics of schizophrenia. AIMS Functional connectivity of the dorsal striatum during reward-related trial-and-error learning was investigated in 17 people with schizophrenia and 18 healthy volunteers and related to striatal grey matter volume and psychopathology. METHOD We used voxe...

The past decade has seen a dramatic change in our understanding of the role of the striatum in behavior. Early perspectives emphasized a role for the striatum in habitual learning of stimulus-response associations and sequences of actions. Recent advances from human neuroimaging research suggest a broader role for the striatum in motivated learning. New findings demonstrate that the striatum re...

Abstract Background In the central nervous system of mammals, transporters localized on presynaptic nerve terminals regulate reuptake neurotransmitters. These are selective for a specific neurotransmitter such as dopamine (DA) and norepinephrine (NE). Specifically in synapse, transporter (DAT) reuptakes DA (NET) NE. However previous research has found that avian species do not have gene DAT, th...

Reinforcement learning theory has generated substantial interest in neurobiology, particularly because of the resemblance between phasic dopamine and reward prediction errors. Actor-critic theories have been adapted to account for the functions of the striatum, with parts of the dorsal striatum equated to the actor. Here, we specifically test whether the human dorsal striatum--as predicted by a...

BACKGROUND The food addiction model proposes that obesity overlaps with addiction in terms of neurobiological alterations in the striatum and related clinical manifestations (i.e., craving and persistence of unhealthy habits). Therefore, we aimed to examine the functional connectivity of the striatum in excess-weight versus normal-weight subjects and to determine the extent of the association b...

Background. the basal ganglia’s circuit dysfunction has a major role in a range of movement disorders. Some evidence has shown that exercise can improve performance, especially locomotor activity after brain injuries. There was currently insufficient information to define the impacts of intensity, duration, and frequency of different exercises. Objectives. in this study, we examine the r...