background: the aim of this study was to assess epidemiology of colorectal cancer (crc) in isfahan, iran. materials and methods: data were gathered from hospital documents of hospital admissions for colonoscopy, surgery, chemotherapy or radiotherapy due to colorectal cancer during 1996-2003. results: 1100 cases with colorectal cancer in seven years were detected and reviewed. our minimum incide...

background: colorectal cancer (crc) is the third most common malignancy in iran. limited data are available on knowledge and barriers in regard to crc and screening tests in iran. the aim of  the study was to characterize knowledge, practice, and barriers toward crc and its screening tests among an iranian at‑risk population. methods: this cross‑sectional study was conducted with participation ...

objective(s): ten-eleven translocation (tet) family members have been shown to be involved in the development of many tumors. however, the biological role of the tet family and its mechanism of action in colorectal carcinogenesis and progression remain poorly understood. materials and methods:we measured the expression levels of tet family members in colorectal cancer (crc) specimens, in the co...

The cryptocephal (crc) mutation causes pleiotropic defects in ecdysone-regulated events during Drosophila molting and metamorphosis. Here we report that crc encodes a Drosophila homolog of vertebrate ATF4, a member of the CREB/ATF family of basic-leucine zipper (bZIP) transcription factors. We identified three putative protein isoforms. CRC-A and CRC-B contain the bZIP domain, and CRC-D is a C-...

Although KRAS and TP53 mutations are common in both inflammatory bowel disease-associated colorectal cancer (IBD-CRC) and sporadic colorectal cancer (S-CRC), molecular events leading to carcinogenesis may be different. Previous studies comparing the frequency of KRAS and TP53 mutations in IBD-CRC and S-CRC were inconsistent. We performed a meta-analysis to compare the presence of KRAS and TP53 ...

PURPOSE Colorectal cancer (CRC) mortality rates in New Mexico (NM) continue to be higher than national rates. Hispanic CRC mortality rates in NM surpass those of overall Hispanics in the US. This study was designed to characterize and understand factors contributing to low CRC screening rates in this border region. METHODS A CRC Knowledge Assessment Survey (KAS) was administered in either Eng...