Interpersonal trust is an essential ingredient of many social relationships. Previous research has suggested that the medial Prefrontal Cortex (mPFC) may be a critical component in mediating the degree to which people trust others. Here we assessed the role of the mPFC in modulating interpersonal trust by means of transcranial direct current stimulation (tDCS). Participants (n = 60) were random...

Dozens of animal studies of transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) have provided insight into the cellular mechanism of stimulation. Biomarkers of tDCS/ tACS responses at the neurophysiological, behavioral, and molecular levels provide a basis to design clinical interventions that engage specifi c targets. This chapter provides a b...

Balance of cortical excitation and inhibition (EI) is thought to be disrupted in several neuropsychiatric conditions, yet it is not clear how it is maintained in the healthy human brain. When EI balance is disturbed during learning and memory in animal models, it can be restabilized via formation of inhibitory replicas of newly formed excitatory connections. Here we assess evidence for such sel...

A new study using transcranial direct current stimulation shows that modulating parietal cortex activity during the learning of abstract numerical material can enhance numerical competency for up to six months.

One hypothesis concerning the neural underpinnings of auditory streaming states that frequency tuning of tonotopically organized neurons in primary auditory fields in combination with physiological forward suppression is necessary for the separation of representations of high-frequency A and low-frequency B tones. The extent of spatial overlap between the tonotopic activations of A and B tones ...

The effects of transcranial direct current stimulation on global/local attentional switching and feature processing were assessed. Direct current stimulation was applied to the left posterior parietal cortex in 14 healthy participants. A compound letter task was used to probe the feature processing and the switching of attention between global and local features. Results indicate that cathodal ...

BACKGROUND Previous research on hemispatial neglect has provided evidence for dissociable mechanisms for egocentric and allocentric processing. Although a few studies have examined whether tDCS to posterior parietal cortex can be beneficial for attentional processing in neurologically intact individuals, none have examined the potential effect of tDCS on allocentric and/or egocentric processing...

Given the current debates about the precise functional role of the right temporoparietal junction (rTPJ) in egocentric and exocentric perspective taking, in the present study we manipulated activity in the rTPJ to investigate the effects on a spatial perspective-taking task. Participants engaged in a mental body transformation task, requiring them to mentally rotate their own body to the positi...