An implantable manually-actuated drug delivery device, consisting of a refillable drug reservoir, flexible cannula, check valve, and suture tabs, was investigated as a new approach for delivering pharmaceuticals to treat chronic ocular diseases. Devices are fabricated by molding and bonding three structured layers of polydimethylsiloxane. A 30 gauge non-coring needle was used to refill the rese...

Abstract Simulation of heavy oil thermal cracking process is very important but few researches have been published now. In this paper, a simulation framework based on the carbon number-based approach(CNCA) has been established. A systematic division rule is put forward for dividing cracked products into 59 carbon number components. Then the cracking reaction network has been structured and the ...

analytical detection of cracking in connections of steel moment resisting frames using simple damage indices is important since these cracks are not visible unless the connections are uncovered. in this paper, applicability of three cumulative damage indices for detection of cracking in a cover plate welded moment connection is investigated. the damage indices considered in this study are based...

Given that concrete masonry walls are expected to experience shrinkage combined with thermal expansion and contraction, and in some cases even carbonation, throughout their service life, cracking is to be expected. However, after concrete masonry walls have been placed into service, originally anticipated and accounted for cracking is often misdiagnosed as a structural defect. Such misdiagnoses...

Analytical detection of cracking in connections of steel moment resisting frames using simple damage indices is important since these cracks are not visible unless the connections are uncovered. In this paper, applicability of three cumulative damage indices for detection of cracking in a cover plate welded moment connection is investigated. The damage indices considered in this study are based...

Though many diagnostic PCR methods have been described, few techniques have been developed to rapidly and efficiently screen transformed bacterial colonies for plasmid presence (1). Unfortunately, PCR screening of a large number of colonies is time consuming and requires substantial amounts of polymerase and primers. In this report, we describe a two-step large-scale bacterial colony screening ...

Quartzite samples of high purity with a grain size ~200 ?m have been experimentally deformed by coaxial shortening in solid medium apparatus at 900 °C and confining pressures ranging from 0.6 to 2 GPa. Most shortened ~30% 0.1 wt% added H2O. The dominantly crystal plasticity (dislocation creep), there is systematic decrease flow stress increasing pressure. Strain rate stepping tests yield expone...

Fruit cracking has long been a topic of great concern for growers and researchers of litchi (Litchi chinensis Sonn.). To understand the molecular mechanisms underlying fruit cracking, high-throughput RNA sequencing (RNA-Seq) was first used for de novo assembly and characterization of the transcriptome of cracking pericarp of litchi. Comparative transcriptomic analyses were performed on non-crac...

The cracking and delamination of TiN-coated hardmetals (WC-Co cemented carbides) when subjected to Brale indentation were studied. Experimental variables were substrate microstructure related to low (6%wt. Co) and medium (13%wt. Co) binder content, and surface finishes associated with grinding and polishing stages before film deposition. Brale indentation tests were conducted on both coated and...

This paper considers the explicit solutions of free-edge stresses near circumferential cracks in surface coatings of circular torsion bars and their application in determining the progressive cracking density in the coating layers. The problem was formulated within the framework of linear elastic fracture mechanics (LEFM). The free-edge stresses near crack tip and the shear stresses in the cros...