نتایج جستجو برای: coxsackievirus b3protease 3c

تعداد نتایج: 9047  

2016
Anna Sävneby Johannes Luthman Fabian Nordenskjöld Björn Andersson A Michael Lindberg

The transcriptomes of cells infected with lytic and non-lytic variants of coxsackievirus B2 Ohio-1 (CVB2O) were analyzed using next generation sequencing. This approach was selected with the purpose of elucidating the effects of lytic and non-lytic viruses on host cell transcription. Total RNA was extracted from infected cells and sequenced. The resulting reads were subsequently mapped against ...

2017
Li Zhang Na Zhao Xiaodan Huang Xiuming Jin Xingyi Geng Ta-Chien Chan Shelan Liu

To understand control interventions, the molecular epidemiology of acute hemorrhagic conjunctivitis (AHC) was investigated from 2004 to 2014.A total of 613,485 AHC cases (annualized cases 55,771) with two deaths were included. Our findings showed that AHC was reported in all provinces, predominantly in Southern and Eastern China. The incidence rates were highest in 2007 (5.65/100,000) and 2010 ...

2015
Yingying Shi Xiaohua He Guoguo Zhu Huilin Tu Zhongchun Liu Wenhua Li Song Han Jun Yin Biwen Peng Wanhong Liu

Autophagy is an important homeostatic process for the degradation of cytosolic proteins and organelles and has been reported to play an important role in cellular responses to pathogens and virus replication. However, the role of autophagy in Coxsackievirus A16 (CA16) infection and pathogenesis remains unknown. Here, we demonstrated that CA16 infection enhanced autophagosome formation, resultin...

2013
Rei-Lin Kuo Li-Ting Kao Sue-Jane Lin Robert Yung-Liang Wang Shin-Ru Shih

Induction of type-I interferons (IFNs), IFN-α/β, is crucial to innate immunity against RNA virus infection. Cytoplasmic retinoic acid-inducible gene I (RIG-I)-like receptors, including RIG-I and melanoma differentiation-associated gene 5 (MDA5), are critical pathogen sensors for activation of type-I IFN expression in response to RNA virus infection. MDA5 is required for type-I IFN expression in...

Journal: :Biochemical Society transactions 2013
Jameel M Inal Samireh Jorfi

Coxsackievirus B1, a member of the Picornaviridae family is a non-enveloped single-stranded RNA virus associated with human diseases including myocarditis and pancreatitis. Infection of the intestinal mucosa, lined by polarized epithelial cells, requires interaction of coxsackievirus with apically located DAF (decay-accelerating factor) before transport to the basolaterally located CAR (coxsack...

Journal: :3C Tecnología_Glosas de innovación aplicadas a la pyme 2017

2015
Xiaobo Feng Wencai Guan Yifeng Guo Huiju Yu Xiaoling Zhang Ruhong Cheng Zhen Wang Zhen Zhang Jia Zhang Huaguo Li Yin Zhuang Hui Zhang Zhiyong Lu Ming Li Hong Yu Yixiao Bao Yunwen Hu Zhirong Yao

A novel recombinant coxsackievirus A6 (CVA6) strain was isolated during a coxsackievirus A6 outbreak in Shanghai, China, in 2013. Genomic sequence and similarity plot analysis showed that the novel CVA6 strain shared higher similarity with a recent CVA4 strain rather than the recent CVA6 strain in the 2C and 3' untranslated regions (UTRs).

2016
Di Sun Shun Chen Anchun Cheng Mingshu Wang

The Picornaviridae family comprises a large group of non-enveloped viruses that have a major impact on human and veterinary health. The viral genome contains one open reading frame encoding a single polyprotein that can be processed by viral proteinases. The crucial 3C proteinases (3C(pro)s) of picornaviruses share similar spatial structures and it is becoming apparent that 3C(pro) plays a sign...

2005
Xiao Qian Chen Yin-Wan Wendy Fung Albert Cheung Hoi Yu

Our recent findings indicate an induced upregulation of 14-3-3c mRNA and protein in ischemic cortical astrocytes. Despite being brain-specific, the functional role of 14-3-3c in the brain still remains largely unknown. In this study, we show that among all the 14-3-3 isoforms, only the c isoform is inducible under ischemia in astrocytes. Furthermore, this upregulation of 14-3-3c may play a spec...

Journal: :Analytical biochemistry 2008
Jin-Ching Lee Shin-Ru Shih Ten-Yuan Chang Huan-Yi Tseng Ya-Feng Shih Kuei-Jung Yen Wei-Chun Chen Jiun-Jie Shie Jim-Min Fang Po-Huang Liang Yu-Sheng Chao John T-A Hsu

Although several cell-based reporter assays have been developed for screening of viral protease inhibitors, most of these assays have a significant limitation in that numerous false positives can be generated for the compounds that are interfering with reporter gene detection due to the cellular viability. To improve, we developed a mammalian cell-based assay based on the reverse two-hybrid sys...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید