Atherosclerosis is a systemic vascular pathology that is preceded by endothelial dysfunction. Vascular inflammation "fuels" atherosclerosis and creates the milieu for episodes of intravascular thromboses. Thrombotic events in the coronary vasculature may lead to asymptomatic progression of atherosclerosis or could manifest as acute coronary syndromes or even sudden cardiac death. Thrombus encou...

Calcium levels in the Coronary Artery are an indicative marker of presence and extent atherosclerosis. This serves as additional prognostic indicator addition to traditional risk factors. Moreover, coronary calcium test is associated with a descriptor known score or (Cs), which primarily useful for stratifying asymptomatic patients, while patients acute chronic chest pain, axial computed tomogr...

BACKGROUND Coronary atherosclerosis, the main cause of cardiovascular disease, is a progressive disease. Recent Genome Wide Association Studies (GWASs) discovered several novel loci associated with coronary artery disease (CAD) or its main complication myocardial infarction (MI). In this study, we investigated the associations between previously reported CAD- and MI-associated variants and coro...

BACKGROUND Arterial stiffness is a physiologic quantitative value used to measure arterial compliance. It is predictive of coronary atherosclerosis in patients with intermediate to high cardiovascular risk. However, a correlation between arterial stiffness and subclinical coronary atherosclerosis has yet to be established. Therefore, the purpose of this study was to evaluate arterial stiffness ...

Abstract Leukocytes and resident cells in the arterial wall contribute to atherosclerosis, especially at sites of disturbed blood flow. Expression endothelial Tie1 receptor tyrosine kinase is enhanced these sites, attenuation its expression reduces atherosclerotic burden decreases inflammation. However, Tie2 function atherosclerosis unknown. Here we provide genetic evidence from humans an mouse...

An elevated plasma total homocysteine (tHcy) level is considered a risk factor for coronary artery disease (CAD), but the relationship between plasma tHcy and well-defined CAD in women is still unclear. Plasma tHcy concentrations and the covariates serum folate, vitamin B12, and creatinine were analysed in 157 angiographically examined postmenopausal women with unstable CAD and in 101 healthy c...

conclusions the scf phenomenon is relatively frequent, particularly among patients with acute coronary syndrome who are scheduled for coronary angiography. hypertension, a low hdl-c level, and high hemoglobin level can be considered independent predictors of this phenomenon. results among the 3600 patients scheduled for selective coronary angiography, 75 (2%) met the scf criteria. scf and neca ...

OBJECTIVE To investigate the association of the three angiotensin converting enzyme (ACE) genotypes, DD, ID, and II, with the occurrence or absence of coronary atherosclerosis and with myocardial infarction and hypertension. DESIGN Cohort analysis study. SETTING North-Italy reference centre. SUBJECTS 388 white Italian patients (281 males; mean age 60.7 (SD 12.5) years) with proven coronar...

  Background and Objectives: Cardiovascular disease is the most common cause of death in developed countries. In addition to traditional risk factors for cardiovascular disease, nowadays, accumulating evidence indicates that a variety of infections contribute to pathogenesis of atherosclerosis,  (We investigated whether Helicobacter pylori infection is related to Prevalence of coronar...

POSITIVE correlation between the degree of coronary atherosclerosis and severity of resulting secondary lesions (cardiosclerosis, myocardial infarction) is far from the rule.' It is also known that even marked stenotic coronary atherosclerosis rarely may fail to produce the changes characteristic of cardiosclerosis or infarction. Moreover, the site of occlusion of a coronary arterial branch by ...