PURPOSE To evaluate the sensitivity, specificity, and test accuracy of corneal biomechanical metrics and anterior segment data in differentiating keratoconus from healthy corneas. METHODS Comparative case series. Patients with and without keratoconus (gender and age-matched) were submitted for complete eye examinations including corneal hysteresis (CH) and corneal resistance factor (CRF) as m...

PURPOSE To describe the distribution and determinants of intraocular pressure (IOP) and indices of corneal biomechanics in an adult British population. METHODS Goldmann-equivalent IOP (IOPg), corneal mechanical characteristics (corneal hysteresis, CH; corneal resistance factor, CRF), and IOP adjusted for corneal factors (IOPcc) were measured. Ocular biometric characteristics were also measure...

AIMS To investigate an influence of mucopolysaccharidosis (MPS)- and Morbus Fabry-associated corneal opacities on intraocular pressure (IOP) measurements and to evaluate the concordance of the different tonometry methods. METHODS 25 MPS patients with or without corneal clouding, 25 Fabry patients with cornea verticillata ≥ grade 2 and 25 healthy age matched controls were prospectively include...

PURPOSE To investigate possible corneal biomechanical changes in patients with diabetes mellitus and understand the influence of such changes on intraocular pressure measurements. METHODS The study group was composed of 120 eyes from 61 healthy control subjects and 81 eyes from 43 diabetic subjects. IOP was measured first with an ocular response analyzer (ORA) and subsequently with a Goldmann...

Purpose: To evaluate the efficacy of the combined treatment of Intacs SK (Severe keratoconus) and corneal collagen crosslinking in the management of advanced keratoconus (KC). Setting: Private laser center, Haifa, Israel. Affiliated to Hadassah Hospital, Jerusalem. Methods: This is a retrospective study. Intacs SK were implanted using manual technique in eyes with moderate-tosevere keratoconus ...

Oh, J. O. (University of British Columbia, Vancouver, B.C., Canada), and E. J. Gill. Role of interferon-like viral inhibitor in endotoxin-induced corneal resistance to Newcastle disease virus. J. Bacteriol. 91:251-256. 1966.-A state of marked resistance to the toxic corneal effects of Newcastle disease virus (NDV) was observed in rabbit eyes after intravenous injection of 10 or 100 mug of typho...

doi:10.3928/1081597X-20110519-01 T raditionally, biomechanical properties of the cornea have been assessed in vitro by measuring stress-strain and Young modulus on corneal strips. In 2005, the Ocular Response Analyzer (ORA; Reichert Technologies, Depew, New York) was launched as the fi rst commercial device claiming to provide in vivo measurements of corneal biomechanics.1 It utilizes a dynamic...

neovascularization of the normally avascular cornea was associated with a notable increase in the expression of the major pro-angiogenic factors, inflammatory cytokines and proteases. the data supporting a causal role for vascular endothelial growth factor (vegf), inflammatory cytokines and matrix metalloproteinase (mmps) are extensive. anti-angiogenic/anti-inflammatory therapy is considered as...

Dear Editor: Changes in the biomechanical properties of the human cornea play an important role in the pathogenesis of corneal dystrophies such as pellucid marginal corneal degeneration and keratoconus. The latter primarily affects young people and is a leading cause of severe visual impairment. Keratoconus is characterized by weakened corneal biomechanics that leads to progressive bulging and ...

OBJECTIVE To investigate the effects of encircling scleral buckle (SB) on corneal biomechanical properties of the cornea and its morphological parameters. METHODS We prospectively examined twelve eyes diagnosed with vitreous haemorrhage undergoing pars plana vitrectomy (PPV), and fifteen eyes undergoing combined PPV and scleral buckle (PPV/SB) for repair of rhegmatogenous retinal detachment (...