نتایج جستجو برای: corneal markers

تعداد نتایج: 250360  

2010
Yiqin Du Danny S. Roh Martha L. Funderburgh Mary M. Mann Kacey G. Marra J. Peter Rubin Xuan Li James L. Funderburgh

PURPOSE Adipose-derived stem cells (ADSC) are an abundant population of adult stem cells with the potential to differentiate into several specialized tissue types, including neural and neural crest-derived cells. This study sought to determine if ADSC express keratocyte-specific phenotypic markers when cultured under conditions inducing differentiation of corneal stromal stem cells to keratocyt...

Journal: :Biology of the cell 2005
Ahdeah Pajoohesh-Ganji Mary Ann Stepp

The anterior one-fifth of the human eye is called the cornea. It consists of several specialized cell types that work together to give the cornea its unique optical properties. As a result of its smooth surface and clarity, light entering the cornea focuses on the neural retina allowing images to come into focus in the optical centres of the brain. When the cornea is not smooth or clear, vision...

2014
Alexandra Mikhailova Tanja Ilmarinen Hannu Uusitalo Heli Skottman

Human induced pluripotent stem cells (hiPSCs) offer unique opportunities for developing novel cell-based therapies and disease modeling. In this study, we developed a directed differentiation method for hiPSCs toward corneal epithelial progenitor cells capable of terminal differentiation toward mature corneal epithelial-like cells. In order to improve the efficiency and reproducibility of our m...

میرصمدی, میرمنصور,

 ABSTRACT The purpose of this study was the evaluation of cycloplegic effect of homatropine 2% on central corneal curvature and power. 43 volunteers who participated in the study were examined. Thirty-nine of them (28 men and 11 women) which had normal eyes with visual acuity of 20/20 and a mean age of 29.6 ± 6.7 years were selected. Then corneal topography was performed on both eyes. After per...

2018
Jing Sun Wei-Hua Liu Feng-Mei Deng Yong-Hui Luo Ke Wen Hong Zhang Hai-Rong Liu Jiang Wu Bing-Yin Su Yi-Lun Liu

Corneal integrity, transparency and vision acuity are maintained by corneal epithelial cells (CECs), which are continuously renewed by corneal limbal stem cells (LSCs). Deficiency of CECs and/or LSCs is associated with numerous ocular diseases. Paired box (PAX)6 is an eye development-associated transcription factor that is necessary for cell fate determination and differentiation of LSCs and CE...

2012
Patrick McNutt Megan Lyman Adam Swartz Kaylie Tuznik Denise Kniffin Kim Whitten Denise Milhorn Tracey Hamilton

A subset of victims of ocular sulfur mustard (SM) exposure develops an irreversible, idiotypic keratitis with associated secondary pathologies, collectively referred to as mustard gas keratopathy (MGK). MGK involves a progressive corneal degeneration resulting in chronic ocular discomfort and impaired vision for which clinical interventions have typically had poor outcomes. Using a rabbit corne...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه علامه طباطبایی - دانشکده ادبیات و زبانهای خارجی 1389

abstract tasks nowadays are at the center of attention in sla research. task types is one of the critical issues in this regard, their effectiveness and suitability to any particular context, their characteristics and the result they yield are among some of these issues. on the other hand, discourse markers (dms) have been very much investigated and their effectiveness in conveying the meaning...

2012
Eszter Szalai Szabolcs Felszeghy Zoltán Hegyi László Módis András Berta Kai Kaarniranta

PURPOSE To determine the extracellular matrix proteins involved in the formation of human granular and lattice type I corneal stromal dystrophies, the expression patterns of fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 were compared in human corneal stromal dystrophy samples. METHODS Ten cases of granular dystrophy, 7 cases of lattice dystrophy, and 6 normal corneal buttons collected d...

2016
Tomislav Sarenac Martin Trapecar Lidija Gradisnik Marjan Slak Rupnik Dusica Pahor

Corneal wound healing is often affected by TGF-β-mediated fibrosis and scar formation. Guided fibrosis with IGF-1 and antifibrotic substances might maintain corneal transparency. Primary human corneal keratocytes under serum-free conditions were used as a model of corneal stromal wounding, with markers of corneal fibrosis and opacity studied under TGF-β2 stimulation. Single-cell imaging flow cy...

2015
Fadhilah Z Abidin Ricardo M Gouveia Che J Connon

Retinoic acid has recently been shown to control the phenotype and extracellular matrix composition of corneal stromal cells cultured in vitro as monolayers. This study set out to investigate the effects of retinoic acid on human corneal keratocytes within a 3D environment. Human corneal keratocytes were encapsulated in collagen gels, which were subsequently compressed under load, and cultured ...

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