In Brazil and several other Latin American countries, Chagas’ disease still constitutes a serious medical and social problem, and there is a need to develop new, more-potent drugs with fewer side effects to effectively treat this disease. We investigated the antitrypanosomal effect of a crude extract, fractions, and a semi-purified subfraction rich in a mixture of isomeric labdane sesquiterpene...

Three new chalcones, 3,2'-dihydroxy-4,3'-dimethoxychalcone-4'-glucoside (1), 4'-O-(2'''-O-caffeoyl)2',3',3,4-tetrahydroxychalcone (2), and 2',4',3-trihydroxy-3',4-dimethoxychalcone (3), along with five known phenolics, were isolated from Coreopsis lanceolata flowers. The structures of the new compounds were elucidated by extensive spectroscopic methods including NMR and MS. The three new chalco...

My talk will focus on the use of the new ECNP nomenclature system to explain the mechanisms of actions of drugs for anxiety and insomnia so that prescribers have a better understanding of their modes of actions and adverse effects

AIM Gastrointestinal (GI) nematodes are considered as a major constraint for successful sheep production. Control of these parasites heavily relies on the use of chemical anthelmintics. Over the past decades, the development of anthelmintic resistance to various groups of anthelmintics and problem of drug residues in animal products has awakened interest in medicinal plants as an alternative so...

Chronic myelogenous leukemia (CML) is a slowly progressive disease characterized by the overproduction of granulocytes (neutrophils, eosinophils, and basophils). A blood smear shows moderate elevations in white blood cell counts that may persist for years and be benign. Platelets are increased in number, although their function is impaired, resulting in symptoms of easy bleeding (purpura, swoll...

Morinda tinctoria (Rubiaceae) is commonly found in the regions of India, Burma, Sri Lanka, Cambodia and Indonesia. This plant is used in the treatment of asthma and bronchitis. Ethanolic extract of whole plant of M. tinctoria was screened for anti-inflammatory activity in carrageenan induced rat paw edema at the dose level 100, 200 and 400mg/kg was compared with the standard drug, Diclofenac so...

Anthemis L. is a genus of aromatic flowering plants in the family Asteraceae and is native to Iran. In this research, 62 accessions of four chamomile species including Anthemis tinctoria, A. triumfetti, A. haussknechtii and A. pseudocotula were evaluated for morphological traits. Four experiments were conducted using a randomized complete block design with three replications at the Research Ins...