We have studied, using a telemetry system, the pyrogenic properties of recombinant murine interleukin-18 (rmIL-18) injected into the peritoneum of C57BL/6 mice. The effect of IL-18 was compared with the febrile response induced by human IL-1beta, lipopolysaccharide (LPS), and recombinant murine interferon-gamma (rmIFN-gamma). Both IL-1beta and LPS induced a febrile response within the first hou...

This paper aims to improve the prediction of rectal temperature (T re) from insulated skin temperature (T is) and micro-climate temperature (T mc) previously reported (Richmond et al., Insulated skin temperature as a measure of core body temperature for individuals wearing CBRN protective clothing. Physiol Meas 2013; 34:1531-43.) using additional physiological and/or environmental variables, un...

Endotherms regulate their core body temperature by adjusting metabolic heat production and insulation. Endothermic body temperatures are therefore relatively stable compared to external temperatures. The thermal sensitivity of biochemical reaction rates is thought to have co-evolved with body temperature regulation so that optimal reaction rates occur at the regulated body temperature. However,...

Key Points Rectal probing is subject to procedural bias. This method is suitable for first-line phenotyping, provided probe depth and measurement duration are standardized. It is also useful for detecting individuals with out-of-range body temperatures (during hypothermia, torpor).The colonic temperature attained by inserting the probe >2 cm deep is a measure of deep (core) body temperature.IR ...

BACKGROUND A decrease in core body temperature caused by heat distribution depends on the anesthetic agent used. The purpose of this study is to investigate the effects of sevoflurane and propofol on core temperature during laparoscopic major abdominal surgery requiring pneumoperitoneum of more than 90 min. METHODS Fifty adult patients undergoing laparoscopic major abdominal surgery were rand...

Ten North American river otters (Lutra canadensis) were anesthetized with Telazol and instrumented with ingestable radiotelemetry temperature sensors for measuring core body temperature. The otters were then subjected to a washing protocol to simulate rehabilitation following an oil spill contamination. This protocol consisted of a 30-min wash in a 1:16 dilution of dishwashing liquid using eith...

THERE IS A CLOSE RELATIONSHIP BETWEEN THE CIRCADIAN RHYTHM OF CORE BODY TEMPERATURE (CBT) AND THE DAILY VARIATION IN VIGILANCE, AS SHOWN by Kleitman.1 Vigilance is optimal during the circadian phase of increased CBT.2-6 Under controlled conditions, the rhythm in CBT results to a large extent from the rhythm in skin blood flow, which determines skin temperature, and the resulting heat transfer g...

Hypothermia during general anesthesia develops with a characteristic three-phase pattern. The initial rapid reduction in core temperature after induction of anesthesia results from an internal redistribution of body heat. Redistribution results because anesthetics inhibit the tonic vasoconstriction that normally maintains a large core-to-peripheral temperature gradient. Core temperature then de...