It is believed that a deficiency of androgens, including free testosterone, may promote the development of convulsions. The present study revealed differences in the action of androsterone (AND), a major excreted metabolite of testosterone and a neurosteroid, in three commonly used seizure models in mice. AND administered intraperitoneally exhibited dose-dependent protection against tonic-cloni...

The involvement of chronic inhibition of monoamine transporters (MAT) in the brain with respect to sensitization to cocaine- and local anesthetic-induced seizures was studied in mice. Repeated administration of subconvulsive doses of meprylcaine as well as cocaine, both of which inhibit MAT, but not lidocaine, which does not inhibit MAT, increased seizure activity and produced sensitization to ...

Rearing is an exploratory behavior induced by novelty, such as exposure to an open field. Stimulation of certain brain regions, including the hippocampus, induces both rearing and clonic convulsions. Brain excitability is controlled by gamma-aminobutyric acid (GABA) inhibitory neurotransmission through its ionotropic GABAA/allosteric benzodiazepine site. Drugs that decrease GABAA receptor fast ...

The aim of this study was to investigate the role of nitric oxide (NO), a second messenger and/or a neurotransmitter, in convulsions induced by nicotine. We examined the effects of 7-nitroindazole (7-NI), a selective neuronal nitric oxide synthase (NOS) inhibitor, N-nitro-L-arginine (NNA), a non -selective NOS inhibitor, and aminoguanidine, a selective inducible NOS inhibitor, on convulsions in...

as a result of which he opened his mouth, looked terrified and began to shiver. Since then he had three ?| four attacks of shivering with convulsions and transien loss of consciousness. Previous history revealed that the boy was moj mischievous and disobedient than others of his age. -fj is said to have been forecasting the weather correctly for the last few years. In fact the neighbours had co...

Objectives: To study the ictal phenomenology, aetiology, and outcome of convulsions occurring within seconds of impact in violent collision sport. Design: Retrospective identification of convulsions associated with concussive brain injury from case records from medical officers of football clubs over a 15 year period. Subjects: Elite Australian rules and rugby league footballers. Main outcome m...

Food intake triggers convulsions in fasted BALB/c mice and Wistar albino rats treated with antimuscarinic drugs, scopolamine or atropine. Inbred strain studies have yielded considerable information regarding genetic influences on seizure susceptibility and factors contribute to epileptogenesis in rodents. This study, therefore, investigated sensitivity to antimuscarinic-induced seizures in C57B...