DEPRESSION IS A LEADING cause of disability in both developed and developing regions of the world, including Africa. In 2000, we conducted a community-based survey in an impoverished part of southwest Uganda that has been severely affected by the human immunodeficiency virus (HIV) epidemic. Using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) major depression cri...

A prospective controlled, double-Wind multicenter trial compared placebo, auranofin (an orally administered gold camplex), and parenteral gold sodium thiomalate (GST) in patients with active rheumatoid arthritis (RA). Of 193 patients who received any treatment, the only important improvement identified for either auranofin or GST was for paidtenderness scores. When 161 patients who completed 20...

Seventy five patients with severely bleeding peptic ulcer were included in a controlled comparative trial to assess the efficacy and safety of endoscopic injection therapy in preventing rebleeding from peptic ulcers that presented at endoscopy with a protruding vessel. Twenty five patients were treated with injection of epinephrine followed by polidocanol, 25 were treated with injection ofabsol...

In 1945 I was looking for a job, after having spent a short post-war convalescence as a junior assistant in the Medical Unit at St. Thomas's Hospital, when I had the good fortune to be introduced to Dr Avery Jones. He had just then had the idea that clues to the causes of gastric and duodenal ulcers might be obtained if differences could be found in the frequency with which they occurred in men...

OSTEOPOROSIS IS A MAJOR cause of disability and excess mortality in older women. Estrogen therapy has been used for treatment and prevention of osteoporosis; however, many older women are reluctant to use it because of adverse effects. Recent data from the Women’s Health Initiative demonstrated that postmenopausal women who took hormone therapy for approximately 7 years had decreased hip fractu...

 A. Carr, DSc FMedSci , Nuffield Professor of Orthopaedic Surgery  C. Cooper, MSc, Senior Trial Manager  J. Rees, MD, Professor of Orthopaedic Surgery and Musculoskeletal Science, NDORMS  D. J. Beard, DPhil, Professor of Musculoskeletal Sciences; CoDirector, Royal College of Surgeons Surgical Trials Unit (SITU-Oxford) University of Oxford, Botnar Research Centre, Windmill Road, Headington, ...

BACKGROUND AND AIM: This prospective study was aimed to compare efficacy and safety of combined surgery and sequential surgeries in patients with primary glaucoma and visually significant senile cataract. MATERIALS AND METHODS: 50 consecutive patients having coexisting visually significant senile cataract with primary glaucoma were included in study. Patients underwent detailed history, ocular ...

Hoog Frequente Oscillaties (80-500 Hz) worden al bijna twintig jaar genoemd als een nieuwe en betere EEG-biomarkervoor het afgrenzen van epileptische hersenweefsel dan de nu gebruikte pieken. Hier wordt resultaat gepresen-teerd unieke zeldzame randomized controlled trial met doel verzamelen prospectieve bewijslastvoor klinische gebruik hoog frequencte osccillaties biomarker tijdens epilepsiechi...