نتایج جستجو برای: contraction to na

تعداد نتایج: 10837640  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1993
E D Moore F S Fay

beta-Agonists cause an inhibition of contractility and a transient stimulation of Na+/K+ pumping in smooth muscle cells of the stomach from the toad Bufo marinus. To determine if the stimulation of Na+/K+ pumping causes changes in intracellular [Na+] ([Na+]i) that might link Na+ pump stimulation to decrease Ca2+ availability for contraction, [Na+]i was measured in these cells with SBFI, a Na(+)...

Journal: :Basic & clinical pharmacology & toxicology 2006
Yong-Xiao Cao Cang-Bao Xu Guo-Gang Luo Lars Edvinsson

The aim of the present study was to investigate if there is an altered expression of alpha-adrenoceptors during organ culture of rat mesenteric artery segments by using a sensitive pharmacological method and molecular biological techniques. Noradrenalin (NA) induced contraction via alpha1-adrenoceptors. The contraction and alpha1A-adrenoceptor mRNA levels were elevated during organ culture. Tra...

Journal: :American journal of physiology. Heart and circulatory physiology 2004
Birgit Bölck Götz Münch Peter Mackenstein Martin Hellmich Ingo Hirsch Hannes Reuter Nadja Hattebuhr Hans-Jörg Weig Martin Ungerer Klara Brixius Robert H G Schwinger

The Na(+)/Ca(2+) exchanger (NCX) may influence cardiac function depending on its predominant mode of action, forward mode or reverse mode, during the contraction-relaxation cycle. The intracellular Na(+) concentration ([Na(+)](i)) and the duration of the action potential as well as the level of NCX protein expression regulate the mode of action of NCX. [Na(+)](i) and NCX expression have been re...

Journal: :Plant physiology 1979
D W Jung G P Brierley

Mitochondria isolated from potato tubers fail to undergo passive osmotic swelling when suspended in isotonic Na(+) acetate or phosphate, in NaCl following addition of tripropyltin, or in Na(+) nitrate following addition of an uncoupler. Swelling under each of these conditions in mitochondria from other sources has been attributed to the inward movement of Na(+) on an endogenous Na(+)/H(+) excha...

2017
Rachel V Floyd Ali Mobasheri Susan Wray

Developmental and tissue-specific differences in isoforms allow Na+, K+-ATPase function to be tightly regulated, as they control sensitivity to ions and inhibitors. Uterine contraction relies on the activity of the Na+, K+ATPase, which creates ionic gradients that drive excitation-contraction coupling. It is unknown whether Na+, K+ATPase isoforms are regulated throughout pregnancy or whether th...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Sebastian K G Maier Ruth E Westenbroek Kenneth A Schenkman Eric O Feigl Todd Scheuer William A Catterall

Voltage-gated sodium channels composed of pore-forming alpha and auxiliary beta subunits are responsible for the rising phase of the action potential in cardiac muscle, but the functional roles of distinct sodium channel subtypes have not been clearly defined. Immunocytochemical studies show that the principal cardiac pore-forming alpha subunit isoform Na(v)1.5 is preferentially localized in in...

Journal: :Molecules 2014
Yan Huang Sheng-Feng Lu Chen-Jun Hu Shu-Ping Fu Wei-Xing Shen Wan-Xin Liu Qian Li Ning Wang Su-Yun He Fan-Rong Liang Bing-Mei Zhu

This study investigated genome-wide gene expressions and the cardioprotective effects of electro-acupuncture pretreatment at the PC6 Neiguan acupoint on myocardial ischemia reperfusion (I/R) injury. Male SD rats were randomly divided into four groups: sham operation (SO), I/R, electro-acupuncture at the PC6 Neiguan acupoint pretreatment (EA) and electro-acupuncture at non-acupoint pretreatment ...

Journal: :Journal of applied physiology 2002
J R Fowles H J Green R Tupling S O'Brien B D Roy

The purpose of this study was to investigate the hypothesis that reductions in Na+-K+- ATPase activity are associated with neuromuscular fatigue following isometric exercise. In control (Con) and exercised (Ex) legs, force and electromyogram were measured in 14 volunteers [age, 23.4 +/- 0.7 (SE) yr] before and immediately after (PST0), 1 h after (PST1), and 4 h after (PST4) isometric, single-le...

Journal: :Experimental neurology 2011
Susanna B Park Cindy S-Y Lin Arun V Krishnan David Goldstein Michael L Friedlander Matthew C Kiernan

Oxaliplatin is first-line chemotherapy for colorectal cancer, but produces dose-limiting neurotoxicity. Acute neurotoxicity following infusion produces symptoms including cold-triggered fasciculations and cramps, with subsequent chronic neuropathy developing at higher cumulative doses. Axonal excitability studies were undertaken in 15 oxaliplatin-treated patients before and immediately after ox...

Journal: :British journal of pharmacology 2010
A Bocquet S Sablayrolles B Vacher B Le Grand

BACKGROUND AND PURPOSE The persistent sodium current is involved in myocardial ischaemia and is selectively inhibited by the newly described 3-(R)-[3-(2-methoxyphenylthio-2-(S)-methylpropyl]amino-3,4-dihydro-2H-1,5-benzoxathiepine bromhydrate (F 15845). Here, we describe the pharmacological profile of F 15845 against the effects of hypoxia in femoral arteries in vitro. EXPERIMENTAL APPROACH I...

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