UNLABELLED To compare Crinone vaginal progesterone gel with intramuscularly injected progesterone for luteal phase support in progesterone-supplemented frozen-thawed embryo transfer (FET) cycles, a randomized prospective study of patients qualified for FET was conducted between September 2010 and January 2013 at a hospital in Shanghai, China. From the day of transformation into secretory phase ...

OBJECTIVE To assess the safety of dextrin sulphate (DS) gel compared to placebo gel in terms of local and systemic adverse events, and to determine the acceptability of dextrin sulphate gel. DESIGN A 4-week randomized trial of DS intra-vaginal gel, partially blinded, with placebo and observation control arms. Participants were randomized to use DS gel twice daily, placebo gel twice daily, DS ...

OBJECTIVE(S) To evaluate the feasibility and acceptability of the Micralax applicator and of methyl cellulose placebo gel for use in vaginal microbicide clinical trials. DESIGN A two-centre prospective study following women for 2 months. SETTING Two primary health care clinics in South Africa. PATIENTS, PARTICIPANTS Female volunteers (n = 28) 18 years or older who were HIV negative and ha...

Introduction: Deeply infiltrating endometriosis (DIE) is defined by the presence of endometrial implants penetrating under the peritoneal surface or under the wall of the pelvic organs to a depth of at least 5 mm. This case report describes a case of DIE involving vaginal wall, periurethral tissue, torus uterinus and sigmoid wall. Case Report: A 46­year­old female was presented with pelvic pain...

The tenofovir trial is being conducted among 1 000 HIV-negative women attending the Ethekwini Clinical Research Site in Durban and the rural Mafakathini clinic at Vulindlela, 90 km Unlike the controversial two failed microbicides (Ushercell cellulose sulphate-based vaginal gel and nonoxynol-9), where trial participants seroconverted, the tenofovir gel does not act in the vaginal lumen to kill t...

The objective of the present investigation was to develop and evaluate microemulsion based gel for the vaginal delivery of Sertaconazole. The solubility of Sertaconazole in various oils, surfactants and co-surfactants were checked to identify components of the microemulsion. The ternary diagrams were plotted to identify the area of microemulsion existence. Various gelling agents were evaluated ...

Our objective was to investigate the first-pass effect to the uterus of progesterone gel administered vaginally. This was a prospective, randomized study of 32 postmenopausal women, attending our menopause clinic. All women used transdermal estradiol (50 microg/day, a patch each week) for 2 weeks. They used either vaginal progesterone gel or intramuscular progesterone in oil 50 mg after 24 h to...

Aim To evaluate the effects of the vaginal erbium laser (VEL) in the treatment of postmenopausal women suffering from genitourinary syndrome of menopause (GSM). Method GSM was assessed in postmenopausal women before and after VEL (one treatment every 30 days, for 3 months; n = 45); the results were compared with the effects of a standard treatment for GSM (1 g of vaginal gel containing 50 μg of...

Objective: A generic vaginal progesterone gel has recently been developed in China. Little is known about its pharmacokinetic properties in Chinese subjects. The purpose of our study was to investigate the pharmacokinetics of three forms of vaginal progesterone gel (test formulations at 4 and 8% strength vs. a reference formulation: Crinone 8%) in Chinese healthy post-menopausal women. Methods:...