linear dynamic response of simply supported nanobeams subjected to a variable axial force is assessed by galerkin numerical approach. constitutive behavior is described by three functional forms of elastic energy densities enclosing nonlocal and strain gradient effects and their combination. linear stationary dynamics of nanobeams is modulated by an axial force which controls the global stiffne...

Signal transducer and activator of transcription (STAT) proteins are involved in hematopoietic cytokine receptor signaling pathways that regulate cell proliferation, differentiation, and survival. STATs are dysregulated in acute myeloid leukemia (AML); mechanisms of dysregulation include constitutive activation and truncation of the C-terminal transactivation domain; the latter results in a bet...

BACKGROUND The melanocortin 1 receptor (MC1R) constitutes a key regulator of melanism. Consequently, many naturally-occurring MC1R mutations are associated with a change in color. An example is the Glu-to-Lys substitution found at position II:20/2.60 in the top of transmembrane helix II which has been identified in melanic mice and several other species. This mutation induces a pronounced incre...

The capability of sand constitutive models is remarkably improved by taking into account the effect of soil state in their formulations. In this study, it has been shown that considering the effect of soil state leads to better simulation of soil instability of shear banding type. To this aim, constitutive equations of a state dependent sand model are explained first. Consequently, the general ...

The main aim of this paper is to study the material removal phenomenon using the finite element method (FEM) analysis for orthogonal cutting, and the impact of cutting speed variation on the chip formation, stress and plastic deformation. We have explored different constitutive models describing the tool-workpiece interaction. The Johnson-Cook constitutive model with damage initiation and damag...

Biomechanical properties of soft tissue, such as liver, are important in modeling computer aided surgical procedures. Experimental evidences show that liver tissue is transversely isotropic. In this article, considering the liver tissue as an incompressible fiber-reinforced composite with one family of fibers, an exponential strain energy function (SEF) is proposed. The proposed SEF is based on...