The role of protein dynamics in the reaction catalyzed by dihydrofolate reductase from the hyperthermophile Thermotoga maritima (TmDHFR) has been examined by enzyme isotope substitution ((15)N, (13)C, (2)H). In contrast to all other enzyme reactions investigated previously, including DHFR from Escherichia coli (EcDHFR), for which isotopic substitution led to decreased reactivity, the rate const...

2 Linear response theory for collective motion 2.1 Intrinsic versus collective response 2.2 Collisional damping of nucleonic motion 2.3 The e ective coupling constant 2.4 Strength distributions 2.5 Transport coe cients and their dependence on T 2.5.1 Friction coe cients in zero frequency limit 2.6 The role of symmetries 2.6.1 Quasi-static properties and the "heat pole" 2.6.2 Consequences for fr...

In this paper, time-domain dynamic analysis of dam - infinite reservoir is studied. A numerical method, discrete singular convolution (DSC), which seems to be efficient and simple, has been used to model the mixed boundary conditions. After a brief introduction, DSC is applied to model the equation of motion of fluid-structure with constant cross section subjected to El-Centro (1940) earthquake...

The accelerating fields (e. g. centrifugal acceleration and constant acceleration) can change the physical performance of nano-sensors significantly. Herein, a new size-dependent model is developed to investigate the scale-dependent dynamic behavior of nanowire-fabricated sensor operated in an accelerating field. The scale-dependent equation of motion is developed by employing a consolidation o...

In this paper natural convection heat transfer within a two-dimensional, horizontal, concentric cam shape cylinders that is partially filled with a fluid saturated porous medium has been investigated. both cylinder are kept at constant and uniform temperatures with the outer cylinder being subjected relatively lower than the inner one. In addition the forchheimer and brinkman effect are taken i...

In this paper a mathematical simulation of a simplified internal combustion engine is presented. To contribute engine kinematics and its geometry, simple relations are derived for constrained motions. The equation of motion for the piston forms a singular boundary value problem. The uniqueness of the solution was studied in the Banach space. For solving governing equations an iterative numerica...

In this paper Mathematical structure of time-dependent Lagrangian systems and their symmetries are extended and the explicit relation between constants of motion and infinitesimal symmetries of time-dependent Lagrangian systems are considered. Starting point is time-independent Lagrangian systems ,then we extend mathematical concepts of these systems such as equivalent lagrangian systems to th...

issues on differences between men and women have always been a source for dispute and different approaches in the available literature on women. some have seen these differences resulting from the dissimilar socialization of men and women in family and society. while some put more emphasis on the physiological differences and rely on theological interpretations, some others consider them as ess...

conclusions the odscp has many advantages over the other type of plates. it can help the surgeon to operate with a relaxed mind and it is advisable for high tibial medial open wedge osteotomies. results the mean follow-up time was 9.33 ± 1.87 month. the average age was 45.13 ± 7.25 years. three patients were male and 13 patients were female. the lysholm score showed a significant difference bef...