The first enantioselective total synthesis of (-)-nardoaristolone B is accomplished by the implementation of an enantio- and diastereoselective copper(I)-catalyzed conjugate addition/enolate trapping sequence and a gold(I)-catalyzed oxidative cyclization (intermolecular oxidant), employed for the first time in total synthesis.

Inventory problems generally have a structure that can be exploited for computational purposes. Here, we look at the duals of two seemingly unrelated inventory models that suggest an interesting duality between discrete time optimal control and optimization over an ordered sequence of variables. Concepts from conjugate duality and generalized geometric programming are used to establish the dual...

Dressed to the nines: The first enantioselective total synthesis of (-)-minovincine has been accomplished in nine chemical steps and 13 % overall yield. A novel, one-step Diels-Alder/β-elimination/conjugate addition organocascade sequence allowed rapid access to the central tetracyclic core in an asymmetric manner. Boc=tert-butoxycarbonyl, LG=leaving group, PMB=para-methoxybenzyl.

The 2022 Ms6.0 Maerkang earthquake sequence, Sichuan, China, occurred in an unexpected area with historically rare seismicity the Bayan Har block. Here we relocated inverted for focal mechanisms of larger events, and calculated rupture directivity sequence to reveal seismogenic structures this sequence. high-precision relocations indicate that consist several clusters are generally parallel nea...

BACKGROUND Pneumococci could evade pneumococcal conjugate vaccines (PCV) by modifying, mutating, or deleting vaccine-serotype capsule genes or by downregulating capsule production. We sought to assess whether pneumococci that are nontypeable (NT) by the Quellung reaction truly lack capsule genes or are failing to produce capsule in vitro. METHODS We applied multilocus sequence typing and a mi...

In September 2006, the seven-valent pneumococcal conjugate vaccine (PCV7; Prevenar) was introduced into the childhood vaccination schedule in the United Kingdom. We monitored the population of invasive pneumococci in Scotland in the 5 years preceding the introduction of PCV7 by using serogrouping, multilocus sequence typing (MLST), and eBURST analysis. Here, we present a unique analysis of a co...

The paper presents optimized methods for PCR and sequence typing of Streptococcus pneumoniae. serotype composition pneumococci isolated from children under 5 years age with infections the upper respiratory tract was analyzed using methods. Between 2016 2021, there a decrease in frequency serotypes included pneumococcal 13-valent conjugate vaccine (PCV13) 94.1 to 25.8%, mainly due 6ABCD serogrou...

A one-pot three-step sequence involving Rh-catalyzed alkene hydroacylation, sulfide elimination and Rh-catalyzed aryl boronic acid conjugate addition gave products of traceless chelation-controlled hydroacylation employing alkyl aldehydes. The stereodefined β-aryl ketones were obtained in good yields with excellent control of enantioselectivity. Good variation of all three reaction components i...

the efficiency and robustness of reliability methods are two important factors in first order reliability method (form). the conjugate choice control (ccc) and directional chaos control method (dcc) were developed to improve the robustness and efficiency of form formula using the stability transformation method. in this paper, the ccc and dcc methods are applied for reliability analysis of a co...

conclusions the prepared antibody can be used for the development of an elisa kit to assay afm1 in milk and other biological fluids. background aflatoxins are the most extensively studied group of mycotoxins produced by molds, especially the aspergillus group, which are highly toxic to animals and humans. objectives since immunoassay is a simple and rapid method for the analysis of many toxic s...