AIMS This study was set up to determine the long term ocular and systemic sequelae in patients with severe congenital toxoplasmosis. METHODS Cross sectional and retrospective study of 17 patients with severe congenital toxoplasmosis. RESULTS In addition to chorioretinitis (100%), the most common abnormal ocular features were optic nerve atrophy (83%), visual acuity of less than 0.1 (85%), s...

We report a case of a newborn male child with congenital toxoplasmosis. During pregnancy seroconversion occurred and positive titers of antitoxoplasmic antibodies (immunoglobulin M and G) were found in the mother, in the third trimester. She received treatment with spiramycin. After birth, the neonate presented with chorioretinitis and intracranial calcifications. The neonate received treatment...

Evidence for the effectiveness of prenatal or postnatal treatment for congenital toxoplasmosis will be critical to guide policy about prenatal and neonatal screening over the next 10 years, let alone the next 100. Randomised controlled trials are needed to address questions about treatment effectiveness, although cohort studies are also needed to provide information on prognosis, especially dis...

BACKGROUND Infection with Toxoplasma gondii is common and usually asymptomatic, although it can have catastrophic consequences in a pregnant woman if passed to her developing fetus. Counseling of pregnant women about risk factor reduction may reduce the risk of congenital toxoplasmosis. This study was undertaken to assess and compare the knowledge of obstetricians and internists or family pract...

In the Supplement entitled “Toxoplasmosis during pregnancy and infancy” [1], the Swiss Working Group on congenital Toxoplasmosis (SWGT) has recommended the cessation of testing for Toxoplasma antibodies before and during pregnancy, arguing the inefficacy of the specific treatment and the low incidence and morbidity of congenital toxoplasmosis in Switzerland. The direct consequences of this deci...

Toxoplasmosis, an infectious and inflammatory syndrome, is one of the most important foodborne diseases causing hospitalization and death in U.S.A. Toxoplasma infects nucleated cells including pancreatic and destroys the β cells. Toxoplasma is a Category B classified infection by CDC and NIH, which once infected the organisms reside in tissues in cysts form for the host's lifelong awaiting reac...

We report a histologic and PCR-confirmed case of symptomatic congenital toxoplasmosis in premature infant with optic nerve atrophy severe ventriculomegaly requiring ventriculoperitoneal shunt the absence cerebral calcifications. A significant risk factor acquisition this infection was mother’s consumption raw deer meat during pregnancy.

Background: Congenital toxoplasmosis results from vertical transmission of the Toxoplasma gondii parasite mother to fetus after a primary maternal infection. The risk fetal contamination is higher later term Conversely, severe infection decreases with term; third trimester infections are most often asymptomatic at birth.