Serum samples from patients with various forms of rubella virus infection were tested for antibodies to each of three viral structural proteins by radioimmunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. In most sera antibody to E1 protein was the predominant species. Sera from patients with congenital rubella syndrome, however, contained significantly more E2 ant...

Examinations were performed on the 108 blind Jamaican children (VA less than 6/60 in the better eye) in residential care. The congenital rubella syndrome (CRS) was the leading preventable cause of childhood blindness, accounting for 22% of children examined. Improvement of the rubella immunisation programme and the introduction of appropriate surgical procedures constitute recent attempts to co...

Ebstein’s anomaly is very rare (0.5 %) cardiac anomaly seen in patient of congenital rubella syndrome. Epidemiology and clinical data are lacking to guide management strategy. Congenital rubella syndrome is manifestation of rubella infection in foetus during period of embryogenesis. A verity of structural heart defect are known to occur with CRS but Ebstein’s anomaly has not been described in a...

Rubella is a contagious viral infection that affects pregnant women during early pregnancy which leads to the infection of a developing fetus, causing congenital rubella syndrome (CRS). Although rare in many industrialized countries, because of the success of vaccination programs, rubella continued to occur in many developing countries with no vaccination program. Rubella immunization rates are...

BACKGROUND As a part of the National Plan for Measles and Congenital Rubella Elimination, a catch-up campaign targeting children aged 7-14 years with Measles-Mumps-Rubella (MMR) vaccine was conducted during 2004-05 in Tuscany, Central Italy. METHODS To assess the profile of measles and rubella susceptibility, immunoglobulin G antibodies against measles (945 subjects) and rubella (1110 subject...

This study was conducted to assess clinical and laboratory screening for suspected congenital rubella syndrome (CRS) and to evaluate the efficacy of reporting of CRS cases at the Children’s Hospital and the Institute of Child Health. A total of 100 infants suspected of having rubella infection were included in the study. Rubella titer was used as an indicator. Enzyme linked immunosorbent assay ...

INTRODUCTION Rubella is generally a mild rush fever disease when acquired in childhood, but when infection occurs during the first months of pregnancy, high risk of trans-placental transmission to the foetus and of congenital anomalies exists. In November 2003, a National Plan for measles and congenital rubella elimination was approved in Italy. The aim was to reduce and maintain Congenital Rub...

In 2003, the Pan American Health Organization (PAHO) adopted a resolution calling for rubella and congenital rubella syndrome (CRS) elimination in the Americas by the year 2010. To accomplish this goal, PAHO advanced a rubella and CRS elimination strategy including introduction of rubella-containing vaccines into routine vaccination programs accompanied by high immunization coverage, interrupti...