نتایج جستجو برای: conformationally restricted
تعداد نتایج: 119548 فیلتر نتایج به سال:
Four stereoisomers of oxy-peptide nucleic acids containing ether linkages in the main chain and conformationally-restricted pyrrolidine rings (pyrrolidine-based oxy-PNA = POPNA) were newly synthesized and investigated for binding to DNA. cis-l-POPNA with 9 adenine bases formed the most stable hybrid with dT(9). The POPNA showed high sequence specificity similar to that of the Nielsen-type PNA a...
High-afnnity analogues of neuropeptide Y containing conformationally restricted non-proteinogenic amino acids Annette G. Beck-Sickinger*t, Eike Hoffmann*, Klaus Padinit, Hans-Ulrich Reissigt, Klaus-Dieter WillimQ, Heike A. WielandQ and Gunther Jung* *Institute of Organic Chemistry, University of Tubingen, Auf der Morgenstelle 18, D-72076 Tubingen, Germany, $Institute of Organic Chemistry, Techn...
Herein, we describe how the conformational differences exhibited by aminoglycosides in the binding pockets of the ribosome and those enzymes involved in bacterial resistance can be exploited in the design of new antibiotic derivatives with improved activity in resistant strains. The simple modification shown in the figure, leading to the conformationally restricted 5, provides an effective prot...
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