نتایج جستجو برای: comt

تعداد نتایج: 1925  

Journal: :Journal of cognitive neuroscience 2014
Christopher T. Smith Theresa Swift-Scanlan Charlotte A. Boettiger

Frontal-dependent task performance is typically modulated by dopamine (DA) according to an inverted-U pattern, whereby intermediate levels of DA signaling optimizes performance. Numerous studies implicate trait differences in DA signaling based on differences in the catechol-O-methyltransferase (COMT) gene in executive function task performance. However, little work has investigated genetic var...

Journal: :Schizophrenia research 2006
Pamela DeRosse Birgit Funke Katherine E Burdick Todd Lencz Terry E Goldberg John M Kane Raju Kucherlapati Anil K Malhotra

Inconsistencies in the relation between COMT variation and schizophrenia may be clarified by careful delineation of a target phenotype. The present study reports a significant association between a COMT haplotype and the severity of manic symptoms in 162 patients with schizophrenia or schizoaffective disorder (SZ). These data suggest that the effect of COMT variation may be associated with como...

2012
Timothy C. Durazzo Kent E. Hutchison Susanna L. Fryer Anderson Mon Dieter J. Meyerhoff

Chronic cigarette smoking and polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol-O-methyltransferase (COMT) are associated with neurocognition in normal controls and those with various neuropsychiatric conditions. The influence of BDNF and COMT on neurocognition in alcohol dependence is unclear. The primary goal of this report was to investigate the associations of single nu...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2004
Majorie B M van Duursen J Thomas Sanderson Paul C de Jong Marlies Kraaij Martin van den Berg

Phytochemicals are natural dietary constituents of fruits and vegetables. Some of these phytochemicals are known to affect estrogen-metabolizing enzymes. In breast tissue, estradiol can be metabolized to the catechol estrogens 2- and 4-hydroxyestradiol (2-OHE(2) and 4-OHE(2)). Catechol estrogens are suspected carcinogens potentially involved in the etiology of breast cancer. Catechol-O-methyltr...

Journal: :Chemical physics letters 2011
Douglas Tsao Shubin Liu Nikolay V Dokholyan

Catechol O-methyltransferase (COMT) metabolizes catechol moieties by methylating a single hydroxyl group at the meta- or para- hydroxyl position. Hydrophobic amino acids near the active site of COMT influence the regioselectivity of this reaction. Our sequence analysis highlights their importance by showing that these residues are highly conserved throughout evolution. Reaction barriers calcula...

Journal: :Molecular medicine reports 2013
Marcio Gerhardt Soeiro-De-Souza Danielle Soares Bio Denise Petresco David Giovani Missio Bruno Lima Fernando Fernandes Rodrigo Machado-Vieira Ricardo Alberto Moreno

Cognitive performance in healthy individuals is associated with gender differences in specific tests; a female advantage has been demonstrated in language tests, whereas a male advantage has been demonstrated in spatial relation examinations. The prefrontal cortex (PFC) mediates important cognitive domains and is influenced by dopamine (DA) activity. The single nucleotide polymorphism (SNP) rs4...

2017
Jiyang Han Yan Li Xumei Wang

Objective The current study aimed to explore the association of single nucleotide polymorphisms (SNPs) within catechol-O-methyltransferase (COMT) and dopamine receptors with schizophrenia and genetic association with risperidone treatment response. Methods A total of 690 schizophrenic patients (case group) were selected and 430 healthy people were included as the controls. All patients receiv...

Journal: :NeuroImage 2010
Stefan Ehrlich Eric M. Morrow Joshua L. Roffman Stuart R. Wallace Melissa Naylor H. Jeremy Bockholt Antonia Lundquist Anastasia Yendiki Beng-Choon Ho Tonya White Dara S. Manoach Vincent P. Clark Vince D. Calhoun Randy L. Gollub Daphne J. Holt

Abnormalities of the medial temporal lobe have been consistently demonstrated in schizophrenia. A common functional polymorphism, Val108/158Met, in the putative schizophrenia susceptibility gene, catechol-O-methyltransferase (COMT), has been shown to influence medial temporal lobe function. However, the effects of this polymorphism on volumes of medial temporal lobe structures, particularly in ...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001
K Mitrunen N Jourenkova V Kataja M Eskelinen V M Kosma S Benhamou D Kang H Vainio M Uusitupa A Hirvonen

We examined 483 Finnish breast cancer cases and 482 population controls to determine the potential effect of catechol-O-methyltransferase (COMT) genotype in individual susceptibility to breast cancer. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression after adjustment for known or suspected risk factors for breast cancer. When studied separa...

Journal: :Journal of the International Neuropsychological Society : JINS 2011
Heather A Wishart Robert M Roth Andrew J Saykin C Harker Rhodes Gregory J Tsongalis Kristine A Pattin Jason H Moore Thomas W McAllister

The Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene may be related to individual differences in cognition, likely via modulation of prefrontal dopamine catabolism. However, the available studies have yielded mixed results, possibly in part because they do not consistently account for other genes that affect cognition. We hypothesized that COMT Met allele homozygosity, whi...

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