the interaction between holo-transferin (htf) and colchicine (col) was investigated in the present of pb +2 ions under physiological conditions by using synchronous fluorescence spectra. the synchronous fluorescence spectra show a slight change of tryptophan residue micro-environment. synchronous fluorescence spectra show that the structure of the tyrosine residue environment was altered by int...

A new tris-chelate Cd(II) complex, [Cd(DADMBTZ)3](ClO3)2 has been successfully synthesized and characterized by IR, 1H, 13C NMR spectroscopy, elemental analysis and single crystal X-ray determination. The thermal behavior, UV-Vis and fluorescence spectra of compound were studied. In reaction with DADMBTZ, Cadmium (II) forms a tris-chelate complex with nearly C3 symmetry for coordination polyhed...

Mitochondria play a critical role in initiating both apoptotic and necrotic cell death. A major player in this process is the mitochondrial permeability transition pore (MPTP), a non-specific pore, permeant to any molecule of < 1.5 kDa, that opens in the inner mitochondrial membrane under conditions of elevated matrix [Ca(2+)], especially when this is accompanied by oxidative stress and deplete...