In this paper, we address the problem of determining the optimal fleet size for three vehicle routing problems, i.e., multi-depot VRP, periodic VRP and multidepot periodic VRP. In each of these problems, we consider three kinds of constraints that are often found in reality, i.e., vehicle capacity, route duration and budget constraints. To tackle the problems, we propose a new Modular Heuristic...

We perform an empirical study to better understand two well-known vulnerability rewards programs, or VRPs, which software vendors use to encourage community participation in finding and responsibly disclosing software vulnerabilities. The Chrome VRP has cost approximately $580,000 over 3 years and has resulted in 501 bounties paid for the identification of security vulnerabilities. The Firefox ...

Abstract We show that the realized GARCH model yields closed-form expression for both volatility index (VIX) and risk premium (VRP). The is driven by two shocks, a return shock shock, these are natural state variables in stochastic discount factor (SDF). endows exponentially affine SDF with compensation risk. This leads to dissimilar dynamic properties under physical risk-neutral measures can e...

This paper focuses on solving a variant of the vehicle routing problem (VRP) in which a time window is associated with each customer service and some services require simultaneous visits from different vehicles to be accomplished. The problem is therefore called the VRP with time windows and synchronization constraints (VRPTWSyn). We present a simulated annealing algorithm (SA) that incorporate...

Over the past decades, the Vehicle Routing Problem (VRP) and its variants have grown ever more popular in the academic literature. Yet, the problem characteristics and assumptions vary widely and few literature reviews have made an effort to classify the existing articles accordingly. In this article, we present a taxonomic review of the VRP literature published between 2009 and 2013. Based on ...

This work was initiated by previous reports demonstrating that mismatched influenza A virus (IAV) vaccines can induce enhanced disease, probably mediated by antibodies. Our aim was, therefore, to investigate if a vaccine inducing opsonizing but not neutralizing antibodies against the hemagglutinin (HA) of a selected heterologous challenge virus would enhance disease or induce protective immune ...

Alphavirus-based replicon vector systems (family Togaviridae) have been developed as expression vectors with demonstrated potential in vaccine development against both infectious diseases and cancer. The single-cycle nature of virus-like replicon particles (VRP), generated by supplying the structural proteins from separate replicable helper RNAs, is an attractive safety component of these syste...

The Vehicle Routing Problem (VRP) is one of the most studied topics in Operations Research. Among numerous variants VRP, this research addresses VRP with relaxed priority rules (VRP-RPR) which customers are assigned to several groups and highest priorities typically need be served before lower ones. Additional used control trade-off between cost efficiency. We propose a Mixed Integer Linear Pro...

Background: Manufacturing companies optimize logistics network routing to reduce transportation costs and operational in order make profits an extremely competitive environment. Therefore, the efficiency of management supply chain quick response customers’ demands are treated as additional source profit. One warehouse operations for intelligent design, called cross-docking (CD) operations, is u...

We compiled an improved version of the G-VRP model of Erdogan and Miller-Hooks (2012) and used it to solve the set of small G-VRP benchmark instances with CPLEX. To be concise, we use the original notation from Erdogan and Miller-Hooks (2012) to describe our model: