AIMS Common variable immunodeficiency (CVID) is the most common serious primary immunodeficiency. This paper describes the immunological consequences of human immunodeficiency virus (HIV) infection in a patient with familial CVID subsequently treated with highly active antiretroviral therapy (HAART). METHODS Serial measurements over 11 years of serum immunoglobulins, specific antibodies to te...

Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and defects in T-cell functions that could be primary or secondary. We addressed whether CVID is associated with impairment in the dendritic cell (DC) compartment, as DCs play a central role in the development of adaptive immunity. We demonstrate that DCs from CVID patients display severely perturbed differentiati...

Background Primary ciliary dyskinesia (PCD) is a rare disorder (prevalence 1/20000), caused by congenital dysmotility of the respiratory cilia. Humoral immunodeficiency (HID) often presents in a similar way with recurrent ear, nose and sinopulmonary infections, not seldom evolving to chronic lung disease. Although isolated IgG subclass deficiencies and IgA deficiency are common conditions, Comm...

BACKGROUND Common variable immunodeficiency (CVID) is one of the most common symptomatic primary immunodeficiency syndromes. The purpose of this article was to broaden our knowledge about CVID for better diagnosis and treatment. METHODS Clinical and immunological features of 40 Chinese patients with CVID were analyzed retrospectively. RESULTS The median age at onset was 11-year-old (range 4...

The relationship between metabolic and inflammatory pathways play a pathogenic role in various cardiometabolic disorders is potentially also involved the pathogenesis of other such as cancer, autoimmunity infectious diseases. Common variable immunodeficiency (CVID) most common primary adults, characterized by increased frequency airway infections with capsulated bacteria. In addition, large pro...

Common variable immunodeficiency (CVID) is the most common form of severe antibody deficiency. The disorder is associated with a broad spectrum of clinical manifestations, including infections and chronic lung, gastrointestinal and autoimmune diseases. A 29-year-old female patient has had frequent sinopulmonary infections and gastroenteritis for the last 20 years and had been given broad-spectr...

BACKGROUND Common variable immunodeficiency (CVID) is defined by hypogammaglobulinemia and increased susceptibility to infections. The gene defect responsible for CVID remains unknown. METHODS During the course of their CVID disease, a female and three male patients developed microcytic anemia. The investigation of this anemia forms the basis for this report. RESULTS Reticulocyte globin cha...

Common variable immunodeficiency (CVID) is characterized by low levels of circulating immunoglobulins, leading to frequent infections, particularly of the respiratory tract. Frequently, T-cell abnormalities are observed. Interleukin-7 (IL-7) is involved in the homeostasis of lymphocytes, and may be elevated in lymphopenia. Mutations of genes related to IL-7 may lead to severe immunodeficiency d...

Introduction: Common Variable Immunodeficiency (CVID) is the most prevalent primary immunodeficiency in adult population. The diagnosis based on low concentration of at least 2 immunoglobulin classes, mostly IgG, with IgA and/or IgM. Beside recurrent infections, patients CVID usually suffer from different respiratory, gastrointestinal, autoimmune and malignant diseases. Leading therapeutic appr...