EDITORIAL Sometimes less is more in multiple sclerosis drug switching Às vezes menos é mais na troca de medicações em esclerose múltipla T he treatment options for relapsing-remitting multiple sclerosis (RRMS), a chronic central nervous system inflammatory demyelinating disorder, have widened in the past decades. Nowadays, medications can significantly reduce the relapse rate and magnetic reson...

A large number of neurodegenerative diseases are caused by impairment of mitochondrial function. Mutations in genes that encode proteins responsible for the shape and dynamics of mitochondria have been associated with some genetic neurodegenerative diseases, which implies that mitochondrial shape plays an important role in the health of neurons and muscle. Neurons are highly dependent on mitoch...

1. Palmer MS, Dryden AJ, Hughes JT, Collinge J. Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease. Nature. 1991; 352(6333):340-342. 2. Dermaut B, Croes EA, Rademakers R, et al. PRNP Val129 homozygosity increases risk for early-onset Alzheimer’s disease. Ann Neurol. 2003;53(3): 409-412. 3. Golanska E, Hulas-Bigoszewska K, Rutkiewicz E, et al. Polymorphisms withi...

Aim of this study was to evaluate in patients with progressive external ophthalmoplegia (PEO) the left ventricular function by standard echocardiography and tissue Doppler imaging (TDI) analysis. Twenty patients with PEO (55.4 ± 17.5 years) and 20 ageand sex-matched healthy subjects underwent standard echocardiography with TDI analysis to assess left ventricular function. TDI was performed by p...

P o r t i o n s of n a t u r a l language con ten t must be d i r e c t l y r e l a t e d to memory func t i o n s in computers . A system should be s e l e c t e d which does not on ly f i t t heo r e t i c a l l y but a l so can be p r a c t i c a l l y 6 a p p l i e d , due to i t s " n a t u r a l " c h a r a c t e r . I t r e p r e s e n t s a d i f f i c u l t task to cut away a usable mo...

A variety of hydrofluorocarbon (HFC) compounds, both as pure substances and mixtures, are being developed as alternative refrigerants to replace the exsting chlorofluorocarbons and hydrofluorocarbons which have been linked to stratospheric ozone depletion. The use ofHFC's in refrigeration systems will require new lubricants, and polyolesters are being widely promoted as the lubricant of choice ...

ABSTH,AGT The two-level morThology model has received a grcal deal oJ attention and ha,s been implcmcnlcd for languages like li'ianish, English, JalmnCSe , Ru,ssian, l,'rcnch, and so on. However, this model has been claimed to be inapproprialc ]or Korean morphological analysis, because the complez" conjugation (inflection) and agglutination in word formation, and the syllabic-based representati...

BACKGROUND The 360° fusion of lumbar segments is a common and well-researched therapy to treat various diseases of the spine. But it changes the biomechanics of the spine and may cause adjacent segment disease (ASD). Among the many techniques developed to avoid this complication, one appears promising. It combines a rigid fusion with a flexible pedicle screw system (hybrid instrumentation, "top...

We des((tile tile design of Comlex Syntax, a co,nputa-tional lexicon providing detailed syntactic iuformation ff)r approximately 38,000 English headwords. We consider the types of errors which arise in creating such a lexicon, and how such errors can be measured and controlled. 1 Goal The goal of the (:omlex Syntax project is to create a moderately-broad-coverage lexicon recording the syntactic...

BACKGROUND Intervertebral disc degeneration is one of the most common reasons for chronic low back pain and sensomotoric deficits, often treated by lumbar sequestrectomy. Nevertheless, the prognostic factors relevant for time and quality of recovery, of the surgical procedure, relative to conservative treatment, remain controversial and require further investigation. Surface electrical stimulat...